Research Group for ME/CFS, Chronic Disease, Aging and Cancer

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  • deffo
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    • August 12, 2021, 02:14:18 PM
deffo quest
« on: August 18, 2022, 03:22:45 AM »
I wanted one place where I could drop anything related - organize my thoughts and ask questions.
I found this site about a year ago but at that time I did not understand the idea behind this protocol. At one point I though I have found solution and I am healthy and then boom - my solution doesnt work anymore and I am depressed again, so depressed I have not felt for 3 years and this scared shit out of me.

Male, born in 1981, ~75kg
Usual symptoms - worst case: Depression, anhedonia, low energy all the time. Took 2-3 naps per day. No supplements work, some nootropics work sometimes (like modafinil, prl-853, phenylpiracetam) but the "hangover" usually follows next day worsening situation. Nicotine makes me sleepy. Max quality working hours per day - 2-3.
Frequent urination, mild gut issues, brain fog after food containing gluten, milk protein and probably seeds like sunflower seeds and cacao.

But in last 3 years I was feeling somehow ok - was able to work 4-5 hours per day, no motivation for extra learning or something useful.

In last 3 years I was taking every possible supplement I found useful. I have taken in various combinations almost everything that is in bornfree protocol.

In the end of 2022 I took stack containing a lot of antioxidants, nootropics and usual stuff like minerals and vitamins and I got in to manic working state. I was working/learning at least 8-10 hours per day + rest of the day playing with my child and being responsible parent in every other ways. And I loved it (if not counting some psychotic episodes).

After 2 months being in this state I took a rest from everything (Christmas), but after that I could not get in to same state with reduced stack of supplements. And then I think I got covid or something like that. But when everyone around me was having some kind of symptoms - I had nothing, just sore throat and maybe a little elevated body temp (also oura warned me about that) for week or so - max 37.5C. From the nootropics I got anxiety so I stopped them. Other supplements did not work at all - so I stopped taking them. I got more and more depressed. I was in such state for almost for half a year.

In the beging of summer I started to get my normal lower level of energy and was able to work 4-5h per day, but still no motivation for anything else. Blamed THC, blamed overused supplements etc.

So here I am, studying this protocol as it makes sense for me.

HTMA ordered. Learning about useful blood tests here in Latvia. Recently my throat infection went a little bit worse - now it feels healed, but I am feeling worse in terms of energy again.

Have not done serology tests. I don't have doctor yet who could help me, but searching for one.

At this point I have 2 suspects:
1) My home (flat in old brick/wooden house) has mold. Because of leak from my flat. Now I can see it on walls. Need to move out from there. I have options to live somewhere else time to time tho.
2) I have at least 1 or 2 dead teeth (removed root canals)


  • deffo
  • New Member

    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #1 on: September 06, 2022, 11:01:16 AM »
I want to tell a story which gave me hope.

I measure my health by quality hours of my life for work, learning and family. Usually I am able to work 4-6h per day (I am software engineer - beginner) and that's it - no more energy and willingness to learn or play with my kid. If I feel very good which is pretty rare for me I can do extra 2h of learning something and I am happy to spend my time with family.

So to fix this I am willing to take every supplement I found to be useful. All this happend before I realised I could be infected with something, so my way of fixing my life was through nootropics.

But... I tried and once I went to manic-working state where I felt really happy, was able to work, learn and was happy to play with my child.

So in 2021 October I felt shitty as usual. I was taking all the possible supplements I could and as always it seems that nothing worked until... Actually on my 40 birthday (06.11) I felt somehow different - better. I felt that I have a lot of energy, excellent mood and motivation. I felt that I can do things, crystal clear head, sharp focus. Besides that I was willing to play with my child. We played silly and simple games and we enjoyed our time together for real!

I took usual supplements like omega 3, magnesium, zinc, vit d, b multi etc.
The list of supplements I was taking is:
October:
Cistanche (Testosterone ^)
BROMANTINE (Probably had some positive effect on kidneys)
BENFOTHIAMINE

November-december:
UNIFIRAM (AMPA receptors ^)
NOOPEPT (ORAL) (HIF ^)

HUMINERAL HUMIC/FULVIC ACID MINERAL (mineral absorption, distribution)
ALCAR (probably related to riboflavin pathway also)

COq10 (UBIQUINONE)
J147 (antioxidant)
EGCG
THERACURMIN (antioxidant)
NAC or NACET (antioxidant)
R-ALA (SDH, AKG-DH ^)
REDUCED GLUTATIONE (antioxidant)
BLACK CUMIN SEED OIL (HDAC inhibitor)
QUERCETINE (antioxidant)
ASTAXANTHIN (antioxidant)
PEA + PQQ

This stack did nothing for me until I switched to low-carb/keto like diet. I have been before on such diets and I would say I always perform better on lowcarb. But this time something was very different.

I was in that manic-happy-working state for 2 months. When Christmas came I stopped using supplements and relaxed. I thought I have found solution and planned to take similar stack after NY. Some more details about my experience being in this state:
  • I was not triggered by junk food/junk info/porn/gaming at all.
  • I was working like factory champ, by clock, being precise and accurate.
  • I was able to do new and complicated things at work. Most of the times thinking before and drawing diagrams and planing etc.
  • When was smoking "empty" weed (without THC) and got high from it like smoking usual joint. Later I realized that there was 1-3% of thc in that home-grown-cbd cannabis I got from my friend. And that high was not typical thc high.
  • Sometimes I got very very frustrating by solving simple everyday tasks. Mostly because I got angry if someone messed up my "schedule".
  • It was very hard to switch tasks.
  • I also did a lot of meditations and yoga which I do rarely.

So after all the partying I thought I will be replicate this but instead of manic-happy state I got anxiety and depression started to creep on me. No supplements/nootropics worked. There were only few things missing from my previous stack:
HUMINERAL HUMIC/FULVIC ACID MINERAL (replaced with shilajit from Russia)
J147
ASTAXANTHIN

Thats it... I was depressed for almost half year. Probably got something like flue/covid. Low energy all the time. Only when summer came I started to regain some vitality.

Now ill go through this bornfree protocol and then probably will test some nootropics (if needed).

Does anyone have some ideas why I was not able to replicate my random superstack? :D


« Last Edit: October 04, 2022, 03:38:31 AM by deffo »


  • deffo
  • New Member

    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #2 on: September 10, 2022, 04:41:44 AM »
So I have finished my 3 day egcg fast. Also Forskolin and trans-pterostilbene (form of resveratrol) was used. From minerals: salt, potasium chloride was used. Magnesium bisglicinate was used only in morning of day 1 with warm salt water for cleaning gut. On day 2 added 1 capsule (500mg) berberine.
So this was least enjoyable fast from them all. I have fasted quite a lot and usually I am fasting for 3 days every 2-3 months for several years. This was my second egcg fast - this time with much larger egcg dose (3x caps Life extension per day).

After the fast I am keeping low carb diet.

My psoriasis red spots on skin retracted a lot - this is by far best result from all the fasts I have done before. Also carnivorish diet helps a lot with psoriasis.

On second day I felt discomfort/slight pain in joints I have problem with, inside eyes-forehead. 

Will repeat! Need to schedule fasts so my body starts to adapt for regular fasting.


  • deffo
  • New Member

    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #3 on: September 13, 2022, 11:57:01 PM »
So I am almost starting Protocol. It will start for real when cyto b2 will be received. For now I am taking minerals in small-moderate doses dissolving them in water with riboflavin and sipping through day.
Added lithium  - felt tingling around neck a few hours later. Wont use it for now as same tingling is observed after eating junk food.
Still waiting for my HTMA results.


  • deffo
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    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #4 on: September 20, 2022, 08:57:39 AM »
My HTMA


  • deffo
  • New Member

    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #5 on: September 22, 2022, 08:30:20 AM »
So I was saying before that taking lithium orotate is making my skin tingling (worsening of psoriasis symptoms) but taking it with humic/fulvic acid does not. Probably lithium is distributed somehow different with humic/fulvic acids or is not absorbed at all.

Also gut feels much better with humic/fulvic.


  • deffo
  • New Member

    • 7

    • August 12, 2021, 02:14:18 PM
Re: deffo quest
« Reply #6 on: November 10, 2022, 02:49:05 AM »
My protocol has been successful so far. I am having great focus and an overall ability to work. Tho my ability to solve problems in my head is still low. Probably due to THC overconsumption. Also, low testosterone/DHT from extended reishi and EGCG use is making me weak and whiny.

I started my protocol at end of summer. At that point, I was 30-40% functional. Able to work, but not able to do anything besides that. Was not as depressed as in spring, but still fighting a lot of self-doubt and self-punishment thoughts.
Ordered copper sulfate on amazon 1kg cheap stuff - not for oral consumption and started to consume it - like 1-2 mg per day - slowly rising dose.
Took all the other minerals. Added humic fulvic acids. That changed a lot - my psoriasis went down a lot. My gut felt better, mood was starting to improve.
Also was taking extra antioxidants: astaxanthin, ergothioneine, quercetin, black cumin seed oil, and reduced glutathione.

After I started the next phase of supplements where forskolin and R-ALA comes in - started to feel better... But still not able to do the job in a high-quality manner.

Then RUBIDIUM came in. I ordered RbCl and Rb Malates from pglchem.com
I used rubidium chloride intranasally ~300mcg - in the same day - after 1-2 hours I felt the urge to work - and I did, and it was a success! Such a level of the workforce inside me I haven't felt for a long time! It felt so natural tho powerful! Rubidium was my game-changer nr1 in this protocol!

So I was able to work, my mood was still swinging and I was a crying bitch sometimes.

When I started reishi par of protocol mood swings were abnormal. Sometimes I was sitting alone at my work just crying not willing to go home showing how weak I felt. After 1 week or so it got better. I took reishi protocol part for 3 weeks. My mood was stable but this reshi effect on 5AR was there. I hoped to get some kind of fiver or reaction from reshi+beta glucans but got only a few small lesions on my face.

Now the protocol has been finished. Learned a lot!!! Learned about the importance of small minerals no one is talking about. NOONE!!! Probably rubidium inst a miracle drug for everyone - it was for me. I am still planning to check what zirconium, cobalt, germanium, and other small little know minerals can do.

Last note. I still felt depressed while not working. Such a state - self-punishing thoughts all the time at the same time able to work - was the first time in my life. I was very internalized - unable to connect with my family. So I dropped in oregano oil and Chaga alcohol extract at the same time. And it reduced this load of self-punishing thoughts a lot - like by 75% at least. Probably oregano doing its bacteria-killing thing in the gut or Chaga triterpenes doing its part...

Also, I have reduced my coffee, nicotine, and THC usage. Don't need those things so much anymore.

So thank you Josh and everyone else in the community for what are you doing there.


« Last Edit: November 10, 2022, 03:00:01 AM by deffo »