An Organic Acids Test (OAT) is a comprehensive report on urine / plasma metabolites.
There are various OAT vendors, and they each have strengths and weaknesses.
For a detailed analysis and interpretation of popular OAT results, automated tools are available here:
Born Free OAT Wizard
and
Metabolic Pathway Overlay
Currently supported tests, (specimen, number of analytes):
Genova Diagnostics NutrEval and Metabolomix, (urine / plasma, ~51)
MosaicDX Organic Acids Test (OAT), (urine, 77)
NutriPATH Organic Acids Metabolomic Mapping (urine, 63)
OMX Organic Metabolomics, (urine / plasma, ~114)
Theriome Aristotle (dried blood-spot, 126) / Plus (dried blood-spot, 296)
Vibrant Wellness Organic Acids Test (OAT) (urine, 77)
The Theriome Aristotle Plus report is clearly the most useful, however also comes at a premium price.
However, any 'traditional' OAT vendor for this protocol will cover the major pathways / intersections, albeit in much lower resolution.
eg.
Mosaic DX,for reasons of reliability, results consistency and marker inclusion has been the go-to for many years.
Vibrant Wellness has an identical array of markers in their OAT panel.
Diagnostics Solutions OMX Organic Metabolomics has a broader array of markers and similar price to the others.
NutriPATH Organic Acids Metabolomic Mapping has a nice, albeit narrower array of inclusions.
Genova Diagnostics NutrEval and Metabolomix are long-established and reliable reports for the core suite of analytes.
Mosaic DX OAT is available through local vendors, or these websites:
International - https://mosaicdxinternational.com/products/mx-organic-acids-test-oat
US -
1) https://www.integrativepsychiatry.net/shop/the-great-plains-laboratory/urine-organic-acids-test/
2) https://empowerednutrition.health/store/Mosaic-Diagnostics-Organic-Acid-Test-p523785023/ (US only)
UK - https://smartnutrition.co.uk/shop/great-plains-oat-organic-acids-test/
UK/EU - https://app.omnos.me/shop/tests/oat-organic-acid-test (needs practitioner)
EU - https://nordiclabs.com/EDetail.aspx?id=2878 (needs practitioner)
AU - via a RN Labs registered practitioner
NZ - https://store.stephenroigard.com/products/organic-acids-test
Diagnostic Solutions OMX Organic Metabolomics can be found at various practitioners and online vendors, such as these:
US - https://charnyhealing.com/products/omx-test-diagnostic-solutions
UK/EU - https://clinicalrevelation.co.uk/products/omx-organic-metabolomics
AU - https://menoguide.com.au/omx-metabolomics-test
NZ - https://www.houseofhealth.co.nz/product/urinary-organic-acids-test/
IN - https://www.ithrive.shop/products/omx-organic-metabolomics-test
Theriome Aristotle Plus
Newer, significantly more data-rich testing options now exist, such as the Theriome Aristotle and Aristotle Plus range of dried blood-spot tests. The Aristotle Plus report currently includes 296 analytes and is far, far superior to traditional OAT reports.
However, this leap in functionality does come at a higher cost. Although the official recommended retail price is >USD$2500, various providers offer them from >USD$800, worldwide.
At this time, I don't have a list of suggested regional vendors that offer direct purchase links. Coming soon.
Note: if there is a pattern of “left shift” or “suspiciously
low” microbial markers on page 1 of the MosaicDX OAT results, it’s possible the
sample has thawed in transit and the integrity compromised, AND/OR the concentration of the sample was out of range (hydration levels). You may need
to repeat the test.
For best results a very short shipping time is
needed and creatinine levels (marker 77) should ideally be between 80-180 mg/dL.
Mosiac DX automatically scale the report markers against the creatinine levels, which can induce a false LEFT-shift with very high concentrations and RIGHT-shift with very low-concentrations. Overall, it's something I think the lab could improve on.
In addition to allowing interpretation of metabolic impairment from the patterns observed in these markers, page 1 of the report shows various markers for microbial interference. The remaining pages show your metabolic impairments from infection and malnutrition. Elevation of yeast, bacterial and fungal metabolites in OAT results have been seen consistently in our collected data, with matching symptoms. A further MycoTOX test may provide further clarity on species and expected metabolic impairments, if required.
Earlier example manual interpretations of these reports can also be found on our Discord online discussion group.
A basic OAT interpretation guide for the purposes of supplement selection can be found in 4 Calculating supplement doses.
Mosaic DX TOXDetect (optional, recommended)
Mosaic DX also provides another urine metabolites test called "TOXDetect Profile", which allows you to quantify the burden of various toxins. Of particular note, 2-Hydroxyethyl Mercapturic Acid (HEMA) in urine appears to be a useful indicator for acetaldehyde, either from exogenous alcohol consumption or fermentation syndrome. However, it is confounded by ethylene oxide and PVC. The metabolism also requires sufficient glutathione for HEMA to be produced. A more direct way to quantify this in urine may be available in the near future.
This test is a little more expensive than the OAT, however can be helpful in monitoring microbiome remediation progress and/or hidden environmental toxins.
This test is available through local vendors, or these websites:
AU - https://www.australianbiologics.com.au/pages/mosaic-diagnostics-test-range
INTL - https://mosaicdxinternational.com/products/toxdetect-profile
NZ - https://store.stephenroigard.com/products/toxic-non-metal-chemical-profile
UK/EU - https://smartnutrition.co.uk/shop/toxdetect-environmental-toxins/
US -
1) https://www.rupahealth.com/lab-tests/mosaic-diagnostics-organic-acids-oat
2) https://mylabsforlife.com/lab-test/toxdetect-profile-urine/