[Dictionary 20260426-1, pre-release for testing purpose - rules are still being added and/or refined]
Vibrant Wellness Organic Acids Test (OAT) is a very useful panel [sample report download] for evaluating catabolic energy metabolism and other key pathways over a defined fasting period + sleep. However, manual interpretation of these reports requires a skill-set and/or billing schedule that is out-of-scope for many point-of-care scenarios. There are known issues where if specimens thaw in transit, are delayed or when creatinine is sufficiently out-of-range, these problems can cause a left or right shift to many values. These reports also lack inferences for intracellular coenzyme, electrolyte and mineral status, which can be provided by the array of analytes reported.
Current features:
1) Client-side javascript extracts the analytes, values and ranges from an unmodified (English, 2023-2026 layout) MosaicDX OAT results PDF, displays them on-screen with a LOW, IN-RANGE LOW, IN-RANGE HIGH, HIGH status, Deviation%, inferred cofactor deficiencies and pattern interpretations, then provides a download function as PDF or CSV (includes a large number of additional columns and can also be used in the Metabolic Pathway Overlay tool).
2) Left or right shift in results, when identified, can be automatically (default) or manually compensated for by adjusting the Shift Correction% input field +/- from 100%. For manual adjustments: A left-shift score is calculated in the totals. Total scores of 50% or above in Req_ShiftCorr suggests shift correction may be appropriate. A common left-shift correction value may be around 150%.
Notes:
1) A deficiency of one redox currency state, eg. NADP implies a functional elevation of the other state, eg. NADPH.
2) Indicated acetyl-CoA deficiency without indicated CoA deficiency suggests glycogen homeostasis / fatty acid oxidation issues.
3) Fe, O2 and antioxidant (Vitamin C /BH4) are used as cofactors in the same hydroxylase reactions, meaning that a deficiency in any 1 of these may impair the reaction and confound the deficiency results for the others. Interpret with caution.
4) Broadly low ATP, TPP, FAD, NAD, P5P, CoA + Acetyl-CoA can indicate low P.
5) Mobile web UI portrait mode support is limited, due to rich table content. Javascript must be enabled in your browser for this tool to work.
6) The extracted analyte values and dictionary-based rules score inferred functional cofactor deficiencies as deviation percentages.
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Disclaimer:
'Vibrant Wellness' and ‘OAT’ are used
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