[v3.8.0 Aristotle Dictionary 20260412-1, Aristotle Plus Dictionary 20260412-1]
Background: Theriome have produced some really lovely panels of analytes (example Aristotle "classic" report) for evaluating metabolic pathway status. However, I feel these amazingly data-rich reports could be better optimised for time-efficient interpretation. They also currently lack some direct measurements of intracellular coenzyme, electrolyte and mineral status - which can be inferred from patterns in the analytes reported. You can now also visualise this data in the Metabolic Pathway Overlay tool.
Current features:
1) Client-side javascript extracts the analytes, values and ranges from Theriome Aristotle report PDFs, or Aristotle Plus CSV files (acquired by manual request to Theriome support), then displays them on-screen with a LOW, IN-RANGE LOW, IN-RANGE HIGH, HIGH status, Deviation%, inferred cofactor deficiency scores and data pattern interpretations, and provides a download function as CSV or PDF.
2) The analyte values are compared to a dictionary file, which contains flags relating to cofactors - ie. coenzymes / minerals / electrolytes required to produce and/or degrade that analyte or rule. These flags and the analyte's value deviation% are then pooled and processed, to calculate an inferred functional deficiency% score, which is displayed as a bar graph percentage. The higher the score, the higher the metabolic impact inferred by the indicated cofactor.
1) A deficiency of one redox currency state, eg. NADP implies an excess of the other state, eg. NADPH.
2) These are early-release dictionaries and rules will be added / updated over time.
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