Hesperidin removed from DIY shake recipe and main protocol pathway (replaced by MB microdosing). Can be used for specific hypometabolic events.

Minor clarity updates. Corrected daily supplement schedule error - was missing Methylene Blue.

Cobalt sources for US, EU, AU updated.

Added content for fungi and metabolic acidosis to Gastrointestinal biofilms and pathogens subsection of 2.2.3 Living without chronic dysbiosis.

Getting started section updated with downloadable daily schedules. Sympathetic overdrive section updated for clarity around influence of impaired nasal breathing + infection / inflammation.

Updated the beginning of paragraph 2 in 2.2.4 The importance of “pacing” or “just enough activity” for clarity, as it was being misinterpreted widely that PEM was fear. Apologies for any confusion.

Inosine added to pre-protocol support and all stages.

Mosaic OAT Interpreter now works with the new v3 2025 report layouts.

Uridine, Mg, P and carbohydrates added to rapid withdrawal support. 60-70% ethanol mentioned in DIY antiseptic subsection of 2.2.3 Living without chronic dysbiosis

Your nervous system sends "predictions", not "facts" subsection added to 2.2.6 Cortisol, limbic system, glycogen and IFN-γ

An easier onboarding process for ordering products, etc. can now be found in the Getting started subsection of "2 The protocol".

D-ribose added to DIY sipper recipe and pre-protocol support.

Uridine monophosphate added to sublingual dosing schedule, pre-protocol support.

Updated DIY sipper, pre-protocol support and electrolytes sections to match monocalcium phosphate product upgrade.

Dicalcium phosphate upgraded to monocalcium phosphate for improved solubility and flavour, plus increased phosphate intake.

Minor updates for clarity in pre-protocol and elecetrolytes section.

Table of parasympathetic influences added to 2.2.6 Cortisol, limbic system, glycogen and IFN-γ, Sympathetic overdrive subsection.

2.2.6 Cortisol, limbic system, glycogen and IFN-γ updated, eATP P2X7 cascade added.

Methylene Blue - "A lifeguard for the NAD+ pool" updated with guidance for non-responder / elevated oxidative-stress subgroup. Dropper bottle recipe instructions added.

Theriome Aristotle and MosaicDX OAT interpreter tools released (see top menu). Oligoscan processor updated to v1.2.0.

Minor adjustments to pre-protocol item inclusions / starting order.

Gut subsection of Living without chronic dysbiosis updated around loss of butyrate producers.

Pendulum Akkermansia replaced with Pendulum Metabolic Daily, which includes butyrate producers.

4.3 DIY sipper - added suggestion for pouring "shots" of the sipper into a glass and topping up with water.

Nootropics Depot NADH replaced with BulkSupplements NAD+ due to ongoing stock availability. ND NADH moved to ALT source.