3 Rationale for protocol inclusions and general notes

wdt_ID	Category	Product	Rationale
18	Amino Acids	Acetyl L-Carnitine	Fatty acid transport, dopamine synthesis promoter.
24	Amino Acids	Creatine	GLUT4, ATP, SAMe metabolism efficiency.
25	Amino Acids	L-Glutamine	Collagen synthesis rate. Promotes IFN-γ. Promotes renal acid excretion.
22	Amino Acids	L-Glycine	Collagen synthesis. Glutathione metabolism.
20	Amino Acids	L-Lysine	Collagen synthesis, antiviral functions.
21	Amino Acids	L-Proline	Collagen synthesis.
23	Amino Acids	L-Serine	Neuropathy, neurotransmission.
17	Amino Acids	Taurine	GLUT2, glycogen synthesis, promotes ALDH for aldehyde degradation, adrenaline inhibition. TUDCA synthesis. Note: can feed Bilophila wadsworthia, etc.
19	Amino Acids	Trimethylglycine	Methylation support, glutathione support, energy metabolism.
70	Antimicrobials	Biofilm Breaker (BP2A)	Start slowly at ¼ capsule. 4 days/week on, 3 days off. This product can cause intense die-off. Please read product instructions. https://ndnr.com/gastrointestinal/biofilms-what-have-we-learned-from-the-research/
71	Antimicrobials	Colostrum	Lactoferrin, IgG. Similar to IVIg, for mucosal tissue – exogenous adaptive immune response.
33	Antimicrobials	Elderberry	Potent source of anthocyanin – antimicrobial, UTIs, etc.
112	Antimicrobials	GI-Synergy (K-64)	Potent herbal anti-microbial with high selectivity.
87	Antimicrobials	Ginger	Antimicrobial food. Inhibits isocitrate lyase. Inhibits MMP-9, preserving glycocalyx.
42	Antimicrobials	Undecylenic Acid	Fungistatic. May add to the aldehyde burden.
98	Antiseptic	Baby Shampoo	Detergent, biofilm breaker.
97	Antiseptic	Biofilm Breaker (BP2A)	Biofilm breaker.
92	Antiseptic	Black Seed Oil	Broad-spectrum antimicrobial and antiviral. Assists dopamine homeostasis.
95	Antiseptic	Boric Acid	Broad-spectrum antimicrobial. Source of boron.
91	Antiseptic	Clove Oil	Broad-spectrum antimicrobial.
105	Antiseptic	Iodine	Broad-spectrum antimicrobial.
94	Antiseptic	NAC	Biofilm breaker, reducer.
93	Antiseptic	Oregano Oil	Broad-spectrum antimicrobial.
108	Antiseptic	Sodium Bicarbonate	Electrolyte. Used to balance pH in various (antiseptic) recipes.
90	Antiseptic	Tea Tree Oil	Broad-spectrum antimicrobial.
15	Electrolytes	Magnesium Aspartate	Critical electrolyte for energy metabolism, etc. Low magnesium can also cause arrhythmia, muscle spasms. Aspartate assists with urea cycle and energy metabolism.
56	Electrolytes	Magnesium Spray	Critical electrolyte for energy metabolism, etc. Low magnesium can also cause arrhythmia, muscle spasms. Transdermal absorption provides a slow release profile.
14	Electrolytes	Monocalcium Phosphate	Calcium - critical electrolyte. Oral dosing works but can feed biofilms. Phosphate - critical electrolyte for energy metabolism (e.g. P5P, glycolysis, etc). Oral dosing is “okay”. Low phosphorus may indicate acidemia - add bicarb.
16	Electrolytes	Potassium Citrate	Critical electrolyte. Oral dosing is okay. Low potassium can cause high blood pressure, arrhythmia, muscle spasms, low glutamate and dopamine synthesis, impaired glycolysis.
107	Electrolytes	Sodium Bicarbonate	Electrolyte. Helpful for buffering lactic acid metabolism and balancing pH.
37	Electrolytes	Sodium Chloride	Critical electrolyte. Oral dosing is okay. Low sodium can cause low blood pressure and low dopamine transport.
88	Food	Oat Bran	Immunomodulation. Manganese. Fibre.
26	Minerals	Bamboo (Silica)	Silicon deficiency – HIF-1a. Antiviral. Magnesium uptake. Collagen. Silica will also be heavily used to excrete acetaldehyde and toxic metals.
131	Minerals	Boron	(Sublingual) Calcium and magnesium retention, hormone synthesis, broad other benefts. Oral route converts into boric acid (see antiseptic) and glycine in the gut.
61	Minerals	Chromium	(Sublingual) Required for glucose transport and insulin sensitivity.
84	Minerals	Cobalt	(Sublingual) EPO regulation. Iron homeostasis. B12 synthesis (microbial). FAD synthesis, P5P synthesis
121	Minerals	Compounded Nutrients	Bypasses oral absorption issues during chronic inflammation. Convenience.
64	Minerals	Copper	(Sublingual) Dopamine precursors. Dopamine beta hydroxylase. CuZnSOD. Glycolysis.
85	Minerals	Germanium GE-132	Antioxidant and other functions.
82	Minerals	Iodine	(Sublingual) Thyroid, riboflavin metabolism. Glucose metabolism. Creatine metabolism.
73	Minerals	Ionic Man	Breaks biofilms. Rubidium - copper metabolism / tissue distribution. Catecholamine metabolism. Strontium - calcium metabolism. Bone density. Transports minerals / toxins during an inflammatory state. Start testing / increasing your tolerance to the fulvic
83	Minerals	Iron (heme)	(Sublingual) Heme. Haemoglobin. Hydroxylase reactions iron-sulphur clusters.
9	Minerals	Kelp	Bromine and iodine source.
58	Minerals	Lithium	Adrenergic metabolism / inhibition. Glycogen‑Synthase‑Kinase‑3β inhibition.. Magnesium reabsorption. Immunity.
74	Minerals	Manganese	(Sublingual) 2 drops. Supports MnSOD. Folate metabolism. Glycocalyx. GDH. Gluconeogenesis (PCB. ME1. PLD).
59	Minerals	Molybdenum	(Sublingual) RIboflavin metabolism. B6 degradation. Taurine metabolism. ALDH. XO.
120	Minerals	Rubidium	Catecholamine homeostasis, copper metabolism. Typical daily intake is 5mg.
60	Minerals	Selenium	(Sublingual) Thyroid and glutathione metabolism.
130	Minerals	Strontium	(Optional) Bone health. Often missing in restricted diets.
62	Minerals	Sulphur	Iron-sulphur clusters. Oxalate transport. Transsulfuration pathway
57	Minerals	Vanadium	(Sublingual) Required for glucose transport and insulin sensitivity.
63	Minerals	Zinc	(Sublingual) Catabolic pathways. Glycolysis. HIF-1a. Methylation + folate transport. BH4. ALDH. LDH. NOS. RK. P5P.
123	Onboarding (Severe)	(Titrating, optional) B1 / TPP	(Sublingual) For onboarding Vitamin B1 with severe / neuropsychiatric symptoms susceptibility.
127	Onboarding (Severe)	(Titrating, optional) B12 / Hydroxycobalamin	For onboarding Vitamin B12 with severe / neuropsychiatric symptoms susceptibility.
124	Onboarding (Severe)	(Titrating, optional) B2 / FMN	(Sublingual) For onboarding Vitamin B2 with severe / neuropsychiatric symptoms susceptibility.
125	Onboarding (Severe)	(Titrating, optional) B6 / P5P	(Sulingual) For onboarding Vitamin B6 with severe / neuropsychiatric symptoms susceptibility.
126	Onboarding (Severe)	(Titrating, optional) B9 / Folinic Acid	For onboarding Vitamin B9 with severe / neuropsychiatric symptoms susceptibility.
8	Prebiotics	Psyllium husk	A teaspoon of powder in a glass of water. Will assist toxin removal, gut microbiome / GI motility.
109	Probiotic	Metabolic Daily	Restores missing butyrate production and A. muciniphila species. Pomegranate supports profileration.
80	Probiotic (per data)	O. formigenes	Promotes oxalate excretion via GI tract. Non-spore-forming.
53	Probiotics	BLIS M18	Oral microbiome support.
54	Probiotics	CFUful Probiotic	300 billion CFU, 24 species, 15 prebiotics, acid-resistant capsule.
55	Probiotics	DrFormulas Nexabiotic for Women	(Also for men.) Bacillus, S. boulardii, + 21 bifidobacterium/lactobacillus, cranberry, d-mannose. Acid resistant capsule.
78	Probiotics	Equilibrium Boost (2 caps)	Broad spectrum species to improve diversity after antibiotic use, etc
81	Probiotics	L. fermentum ME-3	Inhibits pathogenic species, breaks biofilms, produces glutathione.
79	Probiotics	L. sakei (use local sources)	Apply to any mucosal tissues. Non-spore-forming.
31	Supplements	a-GPC	For GI motility and muscle contraction. If muscle stiffness or headache occurs, pause. Acetylcholinesterase is inhibited by Aspergillus mycotoxins and p-Cresol. OAT markers 2-6 and 17 are predictors for sensitivity.
6	Supplements	Apigenin	ALDH, p38 MAPK inhibitor, TGF-b1 modulator and NADase inhibitor. Start at ¼ dose and increase. Upper threshold for effective dose may be 400mg/day.
34	Supplements	Apple Cider Vinegar (ACV)	Start slowly. May cause temporary GI upset, histamine increase. Provides acetyl groups for cellular energy. Supports gut and microbiome via butyrate and SCFA production. Helps break biofilms via butyrate.
35	Supplements	Beta-glucans	(+Ergothioneine) Increases NK cells. May increase histamine / insomnia, low dose.
4	Supplements	Candex	Start slowly. Digests carbohydrates, cell walls, biofilms. You can consume up to 6 of these per day: 1 capsule 15 minutes after food to help digest carbohydrates, three times per day, and 1 capsule three times per day away from meals, to digest microbial
68	Supplements	Chlorella	Start slowly. Will increase sIgA. Pause / reduce as needed. Expect die-off / herxheimer symptoms – headache, rash, sore joints, etc. Potent Vitamin A source.
43	Supplements	Citric Acid	Start very slowly. Prevents oxalate crystal formation. Breaks biofilms. Chelates aluminium. However, it also liberates histamine.
50	Supplements	Curcumin	Start slowly. Will inhibit microorganisms and promote MC1. Inhibits 11HSDβ1. Expect herx. Lower doses can promote NRF2 / decrease inflammation. Higher doses can increase IFN-γ / symptoms by decreasing cortisol release.
119	Supplements	D-Ribose	PRPP / R1P / R5P synthesis, required for NAD+, purine and pyrimidine homeostasis.
47	Supplements	DHA	Lipid membrane maintenance, phosphatidylcholine. Required for ketogenesis.
38	Supplements	Dihydromyricetin (DHM)	Promotes ALDH activity. GI health, neurotransmission, mast cell stabilisation.
10	Supplements	Forskolin	[Optional] Promotes cAMP-PKA during any hypometabolic periods and can be used to taper..
27	Supplements	Green Tea (EGCG)	Reduces nitrogen metabolism, inhibits 11βHSD1, promotes NMNAT2, inhibits glutamate dehydrogenase, inhibits lactate dehydrogenase A, increases zinc absorption. 5-ARi sensitive people may prefer 100mg (active amount) doses, twice per day.
117	Supplements	Hyaluronic Acid	Support glycocalyx assembly, inflammation and leaky junctions, where glycolysis and glutamine are impaired.
128	Supplements	Inosine	(Sulingual) Calms extracellular ATP "alarm signal" P2X7 purinergic relay / Cell Danger Response. Rescues TRPV1 in peripheral neuropathy
13	Supplements	Lecithin	Phosphatidylcholine 2.3g – phospholipid membrane and methylation support, Phosphatidylethanolamine 2g, Phosphatidylinositol 1.4g
122	Supplements	Methylene Blue	Microdosing provides support for Mitocondrial Complex I -> Cytc
116	Supplements	N-AcetylGlucosamine	Support glycocalyx assembly, inflammation and leaky junctions, where glycolysis and glutamine are impaired. Promotes microbials species - see list in 2.2.3 -- Glycocalyx.
29	Supplements	NAC	Thrombolytic, mucolytic, antioxidant, detoxifier, biofilm breaker and metal chelator. Can cause die-off in large doses.
5	Supplements	PQQ+CoQ10	DBH promoter, Electron Transport Chain support. CoQ10 can promote fungal growth.
28	Supplements	R-ALA	ALDH2 promoter. AMPK promoter – insulin sensitivity. Biofilm breaker. Toxic metal chelator. TCA cycle support..
51	Supplements	Reishi	Energy promoter. Immunomodulator. Targets various pathogens. A 1–3 day initial headache is possible when starting reishi. Do not substitute. A USP study found approximately 75% of reishi products are fake.
129	Supplements	Resveratrol	Start slowly. PDH kinase inhibition to help protect against lactic acid excess with improved glycolysis flux vs TCA cycle.. Additional benefits for ALDH, dopamine and microbiome.
32	Supplements	Schisandra	NADPH oxidase inhibitor. Inhibits yeast glycolysis. Immunomodulator.
30	Supplements	Spirulina	Start slowly. Will inhibit microorganisms and promote mitochondrial Complex I. May initially cause nausea, headache, fatigue from fungal die-off symptoms – take this slowly and adjust as tolerable. Vitamin A source.
86	Supplements	Tamarind	Studies show rapid excretion of fluorine in response to tamarind.
118	Supplements	Uridine Monophosphate	(Sublingual) Supports glycogen synthesis, phosphatidylcholine, neural lipid membrane repair, dopamine homeostasis.
115	Tools	Dry Powder Mixer	For DIY shake and sipper preparation
99	Tools	Empty Bottles	Required for temporary storage and dosing of various recipes.
114	Tools	Empty Buckets	For DIY shake and sipper preparation
113	Tools	Kitchen Scales	Assists with measuring food item and supplement weights
103	Tools	Measuring Spoons	For quickly measuring small quantities supplements.
102	Tools	Milligram Scales	For measuring small quantities of supplements.
100	Tools	Needle (25G, 1", x100)	Required for dispensing bacteriophages.
96	Tools	Sinus Rinse	Useful tool for washing out nasopharyngeal and surrounding tissues.
89	Tools	Syringe (20-30mL, Luer slip, x100)	Required for administering mucosal interventions.
106	Tools	Ultrasonic Nebuliser	Allows delivery of supplements, drugs, probiotics and other interventions directly into the lungs.
110	Tools	Vaginal douche	Assists with mucosal interventions in the vagina.
44	Vitamins	B1 Thiamine	TPP / energy metabolism, affected by acetaldehyde. Increase from a tenth dose.
77	Vitamins	B12 Cobalamin	(Sublingual) Methylation. Antioxidant. Catabolic pathways -> TCA cycle.
75	Vitamins	B2 FMN Riboflavin	(Sublingual) Absorbable FMN and FAD support. Has antimicrobial functions.
76	Vitamins	B3 NAD+ / NADH	(Sublingual) NAD+:NADH pool support for wide array of metabolic pathways. IFN-γ activity.
3	Vitamins	B5 Pantothenic Acid	Required for coenzyme A (CoA) and helps regulate lipolysis at VNN1.
66	Vitamins	B6 P5P	Problematic when ALDH deficiency exists, but a critical coenzyme for metabolism.
65	Vitamins	B7 Biotin	(Sublingual) Required for normal energy metabolism, however will feed fungal infections and promote fungal bloom, if infections are not sufficiently inhibited / managed. Oral dosing fails in alcoholism.
2	Vitamins	B8 Myo & D-Chiro Inositol	Myo-inositol + D-chiro inositol. Glucose uptake and glycogen synthesis.
45	Vitamins	B9 5-MTHF	Methylation cycle, BH4.
48	Vitamins	C Ascorbate	Antioxidant. HIF-1a, DBH, collagen synthesis. Use away from copper dosing.
46	Vitamins	D3 + K2	PNMT modulation, immunity, GLUT2, hepcidin/mineral homeostasis.
111	Vitamins	Gamma E Complex	Provides mixed tocopherols and tocotrienols, where diet is lacking or CMA indicates deficiency.

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