[v3.6.8 Dictionary 20260202-1]
Background: Theriome have produced a lovely panel of analytes (example report) for evaluating pathways. However, I feel these reports could be better optimised for time-efficient interpretation. They also lack inferences for intracellular coenzyme, electrolyte and mineral status, which can be provided by the array of analytes reported.
Current features:
1) Client-side javascript extracts the analytes, values and ranges from pages 25-66 of the Aristotle report PDF, displays them on-screen with a LOW, IN-RANGE LOW, IN-RANGE HIGH, HIGH status, Deviation% and provides a download function as CSV or PDF.
2) The analyte values are compared to a dictionary file, which flags cofactors - coenzymes / minerals / electrolytes required to produce and/or degrade that analyte. These flags are summed for all analytes, compared to the total possible, then scored and displayed as a bar graph percentage. The higher the score, the more confidence in a specific inferred cofactor deficiency is provided. Currently, a score above 30% should be treated as a progressively positive indication of deficiency. This will be refined in future updates, when mitochondrial and cytosolic cofactors are separated. Upstream reactions can also be included as required cofactors, with lower 'weights' recorded.
3) A default dictionary is installed (and being further improved), however your own dictionary file can also be used. You can download and extend the existing dictionary schema by adding columns labelled "Req_<cofactor>" and these will be included in the calculations / total. Additional rules can also be defined in the dictionary file, evaluating the variance between 2 analytes against a threshold%, where if this is exceeded, the rule status is set to TRUE and is included in the total flags for cofactors. ie. if Succinic Acid -> Fumaric Acid is out-of-range, FAD, Fe, S, CoQ10 are flagged as potentially low. If the rule's Analyte#2 is "0", the variance% is calculated against ideal (0%). This allows for rules to be created against a single analyte's value.
1) A deficiency of one redox currency state, eg. NADP implies an excess of the other state, eg. NADPH.
2) This is an early-release dictionary and a significant list of rules will be added.
Privacy statement:
No data (the Theriome report or otherwise) is transmitted by your browser, let alone stored on this (or any other) server.
"Upload" buttons on this page are only "uploading" them into your browser cache.
All processing is performed locally, in your web browser.
Disclaimer:
Theriome
and ‘Aristotle’ are used nominatively to identify the compatible PDF
report. Born Free is not affiliated with, endorsed by, or sponsored by
Theriome. This page refers only to Theriome’s metabolomic ‘Aristotle’
report and not to StageZero Life Sciences’ ARISTOTLE® multi-cancer test.
For support with Theriome’s official reports, contact Theriome
directly; this tool is community-built and independent.
Information is general and not medical advice. Outputs
are experimental and may contain errors. Do not use for diagnosis or
clinical decisions; seek advice from a qualified health professional.
This tool is provided for research/education to help read report PDFs.
It is not intended to diagnose, treat, prevent or monitor disease, and
is not intended for clinical decision-support. If you use software for
such purposes, you are responsible for complying with applicable
regulation.
This tool is provided ‘as is’: we don’t warrant
completeness or accuracy and exclude all implied warranties to the
maximum extent permitted by law.