Research Group for ME/CFS, Chronic Disease, Aging and Cancer

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Updated disease model [WIP]
« on: September 25, 2022, 03:08:47 PM »
This is a preview of the hypothetical disease model being described in the upcoming paper.

[Click here to download a PDF version of the experimental intervention protocol based on this work.] (v3.65 RC1 16th February 2024)

These figures are a draft and may contain errors. An interactive version for some of these diagrams is being actively developed and a beta version can be found here, which is currently not working on mobile browsers; however, you can also right-click on the images below and open them in a new tab / save them for high resolution and/or easier navigation.

Questions / discussions - please join our Discord server -

A recorded presentation of the model, as of February 2023 can also be found here:

Errata in video dialogue / content:
2:35 - Interferon-gamma inhibits Complex I and Interferon-alpha inhibits Complex II, not the other way around.
51:50 - NOS reaction should have NADPH as the acceptor and is reversible. See updated diagrams.
59:20 - The "Chief Science Officer" referred to was from Oligolab, not to be confused with Oligoscan, as these are separate companies which both offer this technology. [English subtitles are now corrected. Auto-translation to other languages will be checked.]

An updated presentation of the model, as of August 2023 can be found here:

Figure 1:

Figure 2 (legacy material - being retired/superseded by Figure 3 and will be replaced soon):

Figure 3:

Figure 4:

Figure 5:

« Last Edit: February 15, 2024, 12:30:10 PM by joshua.leisk »
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.