Research Group for ME/CFS, Chronic Disease, Ageing and Cancer

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Calculating mineral dosages?
« on: August 03, 2022, 05:07:13 AM »
Hi All

I saw someone mention this protocol on Twitter and am very curious, particularly about the hair minerals since this ties in with Ron Davis' latest. I've ordered myself a hair test, but wondering if there is a particular formula we are supposed to be using for calculating the dose of the depleted minerals, based on those results? (as per 'Step 3', here)

I also note that there is a caution on manganese tolerance with Lyme, could anyone elaborate on this?
I have been chronically low to deficient in Mn over the years despite multiple rounds of 10mg/day and I never felt better for supplementing it. I've had positive Lyme IgM ELISAs in the past but it's my understanding that this can cross-react with Rheumatoid Factor. Both the follow up Blot testing done by my GP and Armin EliSpot and SeraSpot were negative. The only abnormality was a low CD57+ NK cells, but I can't find much in the literature to validate the significance of this. I'm fully expecting Mn to show low in this hair test but fairly confident I don't have Lyme ???
Thanks


Re: Calculating mineral dosages?
« Reply #1 on: August 03, 2022, 07:45:36 PM »
Hi All

I saw someone mention this protocol on Twitter and am very curious, particularly about the hair minerals since this ties in with Ron Davis' latest. I've ordered myself a hair test, but wondering if there is a particular formula we are supposed to be using for calculating the dose of the depleted minerals, based on those results? (as per 'Step 3', here)

I also note that there is a caution on manganese tolerance with Lyme, could anyone elaborate on this?
I have been chronically low to deficient in Mn over the years despite multiple rounds of 10mg/day and I never felt better for supplementing it. I've had positive Lyme IgM ELISAs in the past but it's my understanding that this can cross-react with Rheumatoid Factor. Both the follow up Blot testing done by my GP and Armin EliSpot and SeraSpot were negative. The only abnormality was a low CD57+ NK cells, but I can't find much in the literature to validate the significance of this. I'm fully expecting Mn to show low in this hair test but fairly confident I don't have Lyme ???
Thanks
Hi there,

What we've observed is that restoring manganese and certain other element levels back into 'normal' range can be quite challenging - this is especially true if iron is also low, as this indicates anaemia of inflammation and extra difficulties with remineralisation, while the inflammatory state is present. Aspects of the protocol target an array of influences towards that inflammatory state. You'll notice 20-40mg of manganese has been suggested in the protocol - even at these levels, it can take months to resolve a deficiency. Regular HTMAs are needed to monitor progress and prevent going into toxicity. The HTMA shows an 'average' of the elements across the time the hair follicle grew. eg. If taking supplements to increase levels, assuming a linear trajectory, a sample taken at 6 weeks would show the progress at approximately 3 weeks.

Given the different roles of these elements in energy and other metabolism, a balance between the 'aggressiveness' of remediating iron and elements involved with oxidative stress management. The bias needs to favour the latter. The means manganese, copper, zinc and selenium (where any are indicated deficient) need to be prioritised ahead of the iron.

Additionally, if there's an active bacterial or other infection, that should ideally be resolved before starting iron, as iron will benefit those pathogenic cells, plus your own metabolism.

Lyme spirochetes make use of manganese to defend against one of the body's defense mechanisms - superoxides. This means again that the process of supporting your own cells gives aid to the foreign cells. Ideally, the protocol would be combined with targeted anti-virals, anti-bacterials or anti-fungals, depending on the pathogenic landscape. Some of the protocol aims to inhibits specific classes of pathogens, at their energy sources, in ways that don't impair your own energy metabolism.

Hope that helps! Feel free to post your HTMA here or on the Discord for further discussion.

Regards,

Joshua
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.