2.3.4 Rapid withdrawal symptoms, hypo/hyper-metabolism section updated with new diagrams, description of the process, interventions, expectations.

Figure 18 added to disease model page. 2.3.2 Remineralisation updated and additional notes on iron supplementation added. 4.3 Compounded nutrients section renamed and updated.

Corrected important typo in Methylene Blue - "A lifeguard for the NAD+ pool" - "0.1%" replaced with "1%"

Acidaemia: a key influence in disease progression added to 2.2.4 The importance of “pacing” or “just enough activity”. Introduction text updated with CREB influence.

Minor typographical errors corrected. Figure 17 added to Disease Model page.

2 - Pre-protocol support and starting order refined.

NAD+ and NMN replaced with sublingual NADH in main, pre-protocol support sections.

Methylene Blue subsection updated, optimal dosing schedule refined. Figure 16 added.

Onboarding sequence for severe patients updated in 2 The protocol. Figure 15 added to Disease Model page.

Methylene Blue subsection updated for clarity and dosing schedule revised.

NADPH: a reductive "currency", powered by TCA cycle flux subsection added to 2.2.4 The importance of “pacing” or “just enough activity”

Methylene Blue - "A lifeguard for the NAD+ pool" subsection added to 2.3.1 Herxheimer / die-off / acetaldehyde support. Figure 14 added to Disease Model page.

Note on carnosine added to 2.3.1 Herxheimer / die-off / acetaldehyde support.

2.2.1 Diet and 2.3.3 Blood-flow, hypoxia and fibrin-amyloid updated with notes around soy isoflavones that inhibit ALDH2, daidzin and daidzein. Figures 12 & 13 added to Disease Model page.

1 Introduction updated for clarity on lactic acidemia's role in the mineral depletion cascade.

Pre-protocol section - NMN replaced with NAD+.

Recovering from severe metabolic and immune collapse (What it feels like and how to navigate the process) added to "1 Introduction." Figures 10 and 11 added to disease model.

Histamine triggers glycogen redistribution subsection text added to 2.2.6 Cortisol, limbic system, glycogen and IFN-γ, 2.2.4 The importance of “pacing” or “just enough activity” and 2.2.9 PEM prevention and recovery.

Fermenting species table and Prescription-based interventions table updated with 3 new species. L-carnosine added to acetaldehyde interventions.

(NEW) Antimicrobial Library added to 2.2.3 Living without chronic dysbiosis under (Prescription-based interventions and other options) subsection.

ALDH2 and 1A1/2/3 table of reactions added to 2.3.1 Herxheimer / die-off / acetaldehyde support. Figure 9 added to Diease Model page.

Active Vitamin A deficiency subsection added to 2.2.1 Diet and Figure 8 added to Disease Model page.

Sympathetic overdrive subsection updated for clarity, with added actionable content. Ketotifen option added to homeostasis reset text.

Sympathetic overdrive subsection and table added to 2.2.6 Cortisol, limbic system, glycogen and IFN-γ.

EU and AU DHM links updated.