Research Group for ME/CFS, Chronic Disease, Ageing and Cancer

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  • Kiwi97
  • New Member

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    • June 23, 2021, 05:15:33 PM
Combining antiviral/antimalarial treatment?
« on: June 23, 2021, 05:26:39 PM »
Hi Joshua, 

I have been experiencing CFS/Fibromyalgia symptoms beginning in 2014 and remaining mild until 2018 where intense fatigue began to develop leaving me in bed for the majority of the day 

Symptoms began after EBV infection without enough rest and became more severe after an HHV6 (confirmed PCR) infection in 2018

Since I have confirmed viral components I think your protocol will be great for me and am excited to give it a try.

However I have also been long considering antiviral/antimalarial treatment and have finally got my Dr on board for the former prescribing 3 months of Valaciclovir. 

What's more I have also been considering artesunate treatment for its broad spectrum nature and known effects on HHV6

Would this treatment be compatible at all with your protocol to be taken concurrently? 

Thank you 



Re: Combining antiviral/antimalarial treatment?
« Reply #1 on: June 24, 2021, 05:45:57 AM »
Hi Joshua,

I have been experiencing CFS/Fibromyalgia symptoms beginning in 2014 and remaining mild until 2018 where intense fatigue began to develop leaving me in bed for the majority of the day

Symptoms began after EBV infection without enough rest and became more severe after an HHV6 (confirmed PCR) infection in 2018

Since I have confirmed viral components I think your protocol will be great for me and am excited to give it a try.

However I have also been long considering antiviral/antimalarial treatment and have finally got my Dr on board for the former prescribing 3 months of Valaciclovir.

What's more I have also been considering artesunate treatment for its broad spectrum nature and known effects on HHV6

Would this treatment be compatible at all with your protocol to be taken concurrently?

Thank you
Hi!

While neither of those are currently known to interfere with the protocol, if someone was considering adding additional parameters to their experiments, it would be a sensible approach not to add them until they'd settled into a stable / quantified state.

If I was performing this kind of self-experiment (and I am, for non-CFS/ME reasons), I would want to get a good feel for the "vanilla" protocol and then be able to quantify the interactions from any additional variables.

Cheers,
Joshua
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.


Re: Combining antiviral/antimalarial treatment?
« Reply #2 on: June 26, 2021, 07:28:36 AM »
I was actually thinking down this line of thinking, as well. Though, more along the lines of oxidative therapies that direct execute virii (e.g. HBOT or IV Ozone)

However, I really think that Valtrex might do more harm during the process since it only blocks one of the two methods of replication at the cost of potentially adding to dizziness and all (I suspect it actually interferes with mitochondrial replication functions...or gut microbial replication functions)

Back in 2014/2015, I was trying a Valtrex 500mg twice daily blockade alone (later added some BHT) when I had what I now understand as a B6 function disruption (or, B6 Toxicity) from a Sublingual B12/B6 supplement (in the form of Pyridoxine). At the time, my major concern was the precipitous drop of Blood counts (WBCs/RBCs/HBG/Platelets) which are now in 2021, abysmal. When I hit the wall with this event, I had no way of being able to isolate what was causing it and halted the Valtrex along with everything else.

Since then, I have had at least three major events, and a whole bunch of mini-events since that mimic the 2014/2015 event and have acquired pretty decent bi-lateral hearing loss/tinnitus, swallowing / GI issues (dysautonomia), and some cardiovascular issues. Though, many of those I can trace aspects of going back prior to the 2014/2015 event.



Re: Combining antiviral/antimalarial treatment?
« Reply #3 on: June 26, 2021, 06:52:47 PM »
I was actually thinking down this line of thinking, as well. Though, more along the lines of oxidative therapies that direct execute virii (e.g. HBOT or IV Ozone)

However, I really think that Valtrex might do more harm during the process since it only blocks one of the two methods of replication at the cost of potentially adding to dizziness and all (I suspect it actually interferes with mitochondrial replication functions...or gut microbial replication functions)

Back in 2014/2015, I was trying a Valtrex 500mg twice daily blockade alone (later added some BHT) when I had what I now understand as a B6 function disruption (or, B6 Toxicity) from a Sublingual B12/B6 supplement (in the form of Pyridoxine). At the time, my major concern was the precipitous drop of Blood counts (WBCs/RBCs/HBG/Platelets) which are now in 2021, abysmal. When I hit the wall with this event, I had no way of being able to isolate what was causing it and halted the Valtrex along with everything else.

Since then, I have had at least three major events, and a whole bunch of mini-events since that mimic the 2014/2015 event and have acquired pretty decent bi-lateral hearing loss/tinnitus, swallowing / GI issues (dysautonomia), and some cardiovascular issues. Though, many of those I can trace aspects of going back prior to the 2014/2015 event.
Overall, I haven't been impressed with what I've seen Valtrex do, either. The dizziness sides get mentioned frequently and the results seem less than spectacular.


Re: Combining antiviral/antimalarial treatment?
« Reply #4 on: December 24, 2021, 03:17:53 PM »
Hi,

Having dealt with ME/CFS for too f*cking long, I have tried most things and worked with some of the best doctors.  If you are going to use anti-virals, then I suggest Famvir which has a better safety profile and fewer side effects and has helped but not cured people especially if you are aware of an EBV infection.  The main key based on my past experiences is somehow getting the immune system back in gear which happened with me with an FMT.  However, finding a healthy person who will agree can be a challenging process especially if you are house bound.  Since I recently went from my best CFS health to the worst in 10 years over the last 2 months, I am investigating Joshua's protocol as it seems to imply boosting immune activity while reducing viral load.