Research Group for ME/CFS, Chronic Disease, Ageing and Cancer

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  • mmmm
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    • June 13, 2021, 11:09:04 PM
Berberine
« on: July 20, 2021, 12:03:12 AM »
Berberine upregulates CD36 ("Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice") - that seems to be beneficial in Hepatitis C models, but not for Coxsackie (as discussed on Discord). Is Berberine something we want in the HHV model?

I'm asking because I would like to try it for its microbiome regulating properties.


Re: Berberine
« Reply #1 on: July 26, 2021, 02:23:01 AM »
Berberine upregulates CD36 ("Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice") - that seems to be beneficial in Hepatitis C models, but not for Coxsackie (as discussed on Discord). Is Berberine something we want in the HHV model?

I'm asking because I would like to try it for its microbiome regulating properties.
I think there could be possible benefits, when pulsed. I noted some concerns in the first paper, also.

If I was experimenting with it, I'd probably test that as an evening dose.
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.


  • mmmm
  • New Member

    • 26

    • June 13, 2021, 11:09:04 PM
Re: Berberine
« Reply #2 on: July 29, 2021, 03:40:09 AM »
Berberine upregulates CD36 ("Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice") - that seems to be beneficial in Hepatitis C models, but not for Coxsackie (as discussed on Discord). Is Berberine something we want in the HHV model?

I'm asking because I would like to try it for its microbiome regulating properties.
I think there could be possible benefits, when pulsed. I noted some concerns in the first paper, also.

If I was experimenting with it, I'd probably test that as an evening dose.
Awesome. Thanks, as always ;D


Re: Berberine
« Reply #3 on: July 29, 2021, 05:46:10 PM »
From what I understand, it is very poorly absorbed.  As in less than 0.5% is absorbed.

Companies are working on ways to enhance absorption.

It is a very nice selective anti-microbial agent, though!