Research Group for ME/CFS, Chronic Disease, Aging and Cancer

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A gentle introduction to the protocol
« on: June 21, 2021, 08:11:26 AM »
The protocol is based on the work of Joshua Leisk. It helps the body get rid of bad cells, like those infected by certain viruses, and hopefully certain cancers. Many people have followed this protocol and have seen improvements in their conditions. But, it is still brand-new, and clinical trials are still being organized. Be careful, and proceed at your own risk.

There are three main parts of the protocol. They are the loading phase, the fasting phase, and the maintenence phase.
People with very low levels of infection might not need the loading phase. The fasting phase can be skipped if you're worried about fasting or don't have a supportive environment for it. But, the protocol works best if all parts are followed closely.

This is optional, but highly recommended.

In the fasting phase, you drink only plain water mixed with a special set of supplements. It is very, very important to not eat or drink anything else, as doing so could hurt you. It is also very important to have a certain supplement on hand at all times. It will help you if you run into trouble, and let you exit the fast at any time. It is strongly recommended to make sure that you have friendly helpers around to assist you through this part of the process and help keep you safe.

This sounds scary, and it is! But, the advantage is that this will let your body get rid of a huge amount of bad cells all at once. It might save weeks, months, or more of time on the maintenance phase. In certain diseases, such as some cancers, fasting might be important for the protocol to work at all. You will also very easily lose body fat, which many people find helpful.

This is like a gentle introduction to some of the later steps. This will help get your body ready to get rid of bad cells. It might also help you get used to a schedule of taking supplements.

In the maintenance phase, you take a specific set of supplements at certain times during the day. You also eat a special kind of diet. This will help your body 'see' the bad cells, and also, give it the tools it needs to get rid of them. It's important to follow both the diet and the supplements exactly as described. Skipping parts won't let the protocol work as well, or at all.

When your body starts seeing bad cells and getting rid of them, you can expect to feel like you've gotten sick. It's usually not very much fun. But, this is your body healing itself. It will pass eventually, and you'll feel much better afterwards.

This can occur at several parts of the process. It can happen during the fasting phase, and/or during the maintenance phase. It's important to be gentle to yourself, and plan to give yourself some time off from daily life. Think of it like a planned sick holiday.

Later on, after your body has gotten through some of the sick parts, some of the supplements can be adjusted to increase or decrease how intense any remaining sickness is. Unfortunately we can't skip all of them, but you can "slow down" the last part of the treatment. This might help if you can only take a certain amount of time off from daily responsibilities, and need to be able to feel your best at other times. Or, if you're handling it very well, you can turn it up and help your body get rid of the bad cells as quickly as possible!

If you are by yourself, you can skip the fasting phase for now. It's important to have help and support during it, and you can always do the fast later.

Otherwise, I highly encourage following the full protocol! This will give you the best chance of the protocol working to its full effect. It will be tough, and it will test you. I've done it myself. I am very glad I did and would happily go through it again.


- Click on this link and find the PDF of the schedule for your location:
- Order all of the supplements from the list.

It's important to use the vendors listed. We don't use referrals, have backroom deals, or otherwise make any money from them! We only list them because we've done our best to make sure that the products contain what they say they do. This is very important for the protocol to work!

- Wait for all of the supplements to arrive! It's exciting to get started, but it would be bad if you didn't have something you needed when you needed it.

- Next, follow the instructions for the proper section you're going to start with.
- A primer on diet can be found here:

- Follow the fasting plan as described in the paper here (see page 23 and beyond):

- Follow the diet plan and the supplementation protocol under Phase one as described in the protocol here:

- Follow the diet plan and the supplementation protocol under Phase two as described here:

Happy virus killing! :D
« Last Edit: June 24, 2021, 05:20:54 AM by joshua.leisk »

Re: A gentle introduction to the protocol
« Reply #1 on: June 22, 2021, 03:02:27 AM »
Wow, this an incredibly well-written and friendly introduction. Thank you, Ian!

For all of the logical reasons, I cannot suggest that anyone embarks on an experimental protocol that hasn't completed clinical trials, even if it "just" involves readily-available dietary supplements and has a growing and supportive community of people, who have seen enough benefits to share the details with family, friends and complete strangers. Loudly.

This is early work, with a goal of being a 'one-size-fits-all' approach. It is experimental. Personal circumstances may vary. There are risks involved with any kind of self-experimentation.

Some of the early self-experimenters needed assistance with understanding what adjustments may improve their progress and outcome. We've also had some important lessons about drug interactions, both positive and negative.

eg. One of these positive interactions caused the listed EGCG dose in the v3.2 draft to be insufficient (1/7th the dose needed) to achieve the desired purpose of normalising GDH, as early testers had also been using Spironolactone, which also positively affected GDH. There were only small numbers of people providing feedback at that time and was very early work.

We've learned that Vitamin D status is a critical factor, as are serum ferritin levels. All of these details have been incorporated in the recent updates.

All information collected and general feedback is being considered for ongoing improvements / refinements to the experience, alongside further research. More data and community involvement provides more opportunities to learn about individual factors that interfere or alter the processes.

People with eg. unquantified serology and co-infections may run into unexpected problems. There are some known biomarkers that are predictive of non-HHV infections, such as low FSH in males (eg. <2IU/L). These may coincide with PSSD.

People with compromised immune functionality may have a different timeline to journeys being blogged here.

Further research into other pathogens, such as enterovirus variants, mycotoxins, spirochetes and others is being actively conducted

eg. We've found that the literature describes metabolic alterations from some pathogens, like giardia, coxsackie and t.gondii that can directly cause the same metabolic cascade being described in the model, however triggered from different inputs / enzymatic alterations.

These co-infections are expected to prevent symptomatic remission being achieved by the experimental protocol while addressing any known HHV infection and evidence suggests that additional remediation efforts for this infections will be needed. This area is my current focus.
« Last Edit: June 22, 2021, 03:05:20 AM by joshua.leisk »
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.

Re: A gentle introduction to the protocol
« Reply #2 on: June 23, 2021, 11:40:08 AM »
Thanks for the informative post. I have a couple of questions:

1) I believe PHASE ONE is no different than the FASTING PHASE (they both reference following the protocol on page 23+). If I'm mistaken please let me know.

2) How long is the MAINTENANCE PHASE to be followed? Are dosages variable/subject dependent? 

Re: A gentle introduction to the protocol
« Reply #3 on: June 24, 2021, 05:38:45 AM »
Thanks for the informative post. I have a couple of questions:

1) I believe PHASE ONE is no different than the FASTING PHASE (they both reference following the protocol on page 23+). If I'm mistaken please let me know.

2) How long is the MAINTENANCE PHASE to be followed? Are dosages variable/subject dependent?
Hi, good eyes - thanks - I've just edited Ian's post to correct the order of sequence in the protocol.

The maintenance phase has an unknown duration and will be related to individual factors. It may run for some months.

EGCG may need adjusting, based on brand, batch, personal circumstances.

LOLA (if used for the induction phase) can be variable between people, according to their reports. Some people find 500mg is enough to make them sleepy. Others have reported no sleepiness at 5g (although this is also suggestive of a high dopamine state, which may indicate a co-infection with coxsackie, which is currently being actively researched, as it appears to be the primary cause for non/partial responders). 

By using tested brands / products, the process should be more predictable. 

The diet is a daily variable and needs to be carefully maintained. With activity increases, more low-GI carbohydrates will likely become appropriate.

Other items shouldn't need any alterations. 

It's possible that after much of the intense immune response has calmed down that a "lite" version of the protocol may be sufficient. This is being considered at the moment and we'll have more updates in coming week/months.

Re: A gentle introduction to the protocol
« Reply #4 on: June 24, 2021, 12:15:34 PM »
Understood, thanks for the information.