Research Group for ME/CFS, Chronic Disease, Ageing and Cancer

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  • mmmm
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    • June 13, 2021, 11:09:04 PM
mmmm's blog
« on: June 14, 2021, 01:01:48 AM »
This is mmmm's blog, where I post updates when I feel the need, or am asked to.

Here's some info about me (copied from Discord - please use `mmmm` to address me here, that's more anonymous):

- Probably mild CFS, undiagnosed. Sometimes very mild nowadays. No labs done ever since I deal(t) with medical anxiety. That's way better now, so considering doing tests if they are not too expensive.
- First health decline 15y ago (age 20), after a multi-week episode of laying in bed what was probably EBV, but could've been any other virus really. I had been drinking alcohol a lot for months every day, so I guess I predisposed myself to this.
- 4y ago only could spend every other day outside of bed. Got a lot better with lipo C and improving airflow in the bedroom, obviously was severely sleep deprived (O2 problems might hint @ arsenic right? My son's HMAT showed super high arsenic too).
- Discovered near infrared irradiation 4y ago, that was a life changer. Can elaborate if someone's interested. Got way better within a few months.
- Cutler chelation (started 2y ago) also improved things a lot (ALA microdosing, never tried bigger doses). Brain works way better now, which is important because I'm a coder.
- Went quasi-vegan 2y ago and that also helped greatly. Cannot eat gluten. Strictly no alcohol. Some sugar sometimes.
- Have been doing 20/4 IF for two months to lose weight, works great so far as. Taking cordyceps tea, milk thistle tea, lipo C + zinc
- Still, have to juggle supps and various protocols to keep feeling well.


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #1 on: June 14, 2021, 01:18:37 AM »
What I'm doing right now:

- Checking out whether I tolerate the recommended supps. Reishi, Lion's mane, and EGCG extract all seem to work - while not feeling great on them, I can imagine taking them long term.
- I've been taking, for 3 days now, the following per day (all alcohol extracts): 6-8g Lion's mane, Reishi 3-4g, EGCG 400-600mg
- Effects were that I felt ~60-70% sick for 2 days - lots of sweating, especially nightsweats. Felt quite depressed today (coming from the gut) until I loaded up on cordyceps. Couldn't concentrate well.
- I need to work now a few days, so I'll leave away the mushrooms for now, and take some EGCG in the early afternoon, in the last 4h of my IF fasting window. To starve infected cells a bit more :P
- Reading up more on the protocol before I get more serious. Waiting for LOLA to arrive.


Re: mmmm's blog
« Reply #2 on: June 14, 2021, 01:37:20 AM »
Hi Mmmm,

One key part of the protocol to clarify is that while discontinuing the beta-glucans will reduce the immune response, reishi controls a lot more than the immune response - it also helps maintain the metabolism remediation.

For this reason, if you discontinue reishi, even for 1 or 2 days, the purine nucleotide cycle issues will reoccur. This means that you're expected to revisit the initial "induction phase crash" all over again.

It's not recommended.  ;)

-Josh
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #3 on: June 14, 2021, 01:54:08 AM »
Great to know, I'll also keep up the Reishi then! Thank you Josh for keeping an eye out!


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #4 on: June 14, 2021, 11:59:47 PM »
Day 5 (14 June 2021)

- 6g Reishi (LFE)
- ~300mg EGCG in the afternoon, during the last 4h of the fasting window
- Tried 2g Mg-Threonate (LFE) for the first time. Immediately felt more relaxed, and cognition/memory improved after a few hours. Seems I have been Mg deficient for a while - maybe the transdermal spray doesn't fully cut it.


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #5 on: June 15, 2021, 12:03:17 AM »
Day 6 (15 June 2021)

- Felt strange in the morning, certainly from the Mg-Threonate. Felt like part of the brain was too wired for its own good and I needed to calm down actively. Excitotoxicity? Excess Glutamate maybe?
- 15h into the fasting window, took 2nd reishi dose and 150mg EGCG. 30m later, felt a few times like losing control. Not quite like fainting (yet), but in that direction. Could be too low blood sugar, unfortunately don't have a test kit right now. I do suspect the Mg Threonate in all this, so will keep watching that.
- Took 0.5g Glycine and 2000 IU D3, and my brain rebooted 30 minutes later - cognitive funtions are almost fully restored. Weird!

Supps on that day:
- 8g Reishi (LFE)
- 150mg EGCG
- 0.5g Mg-Threonate in the evening
« Last Edit: June 16, 2021, 02:32:11 AM by mmmm »


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #6 on: June 16, 2021, 02:35:23 AM »
Day 7 (June 16 2021)

- Learned my lesson yesterday and started taking 0.5g Glycine regularly. The Mg-Threonate seems to work now with the lower dose (0.5g in the evening). Focus and mood are great, so far.
- 4g of Reishi, 380mg EGCG, 2g Glycine today
« Last Edit: June 17, 2021, 01:11:11 PM by mmmm »


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #7 on: June 17, 2021, 01:07:56 PM »
Day 8 (June 17)

- LOLA arrived today, I took half a teaspoon. Sweated a lot for a few hours, and felt wired, but not bad.
- ~2g LOLA, 4g Reishi, 190mg EGCG, 4g Lion's Mane, 15g oat bran, 10g Glycine, 0.5g Mg-Threonate, lots of sunlight

The beta-glucans definitely work, got stuffed ears and that hot/cold feeling soon after.

And, then, in the evening...

My anxiety was completely gone!
At least for a few minutes. This felt very weird. I never felt like this, maybe ever (or at least since kindergarten). CBD & co muted or masked my anxiety, but it never went away so profoundly. For these few minutes, I felt like a super confident person. That I could achieve stuff without fighting for, or fretting about it. This is big, and shook my world a little bit.
I can't pin down yet what give me this confidence boost, but it started building up earlier in the day, so I think it got started by the LOLA, and the oats hit it off.

PS: Oat bran with some water and a few grams of Glycine is delish!
« Last Edit: June 17, 2021, 01:19:32 PM by mmmm »


Re: mmmm's blog
« Reply #8 on: June 17, 2021, 06:20:42 PM »
that's very curious man, do you think it was the aspartate replenishing that got you this response??


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #9 on: June 18, 2021, 12:21:22 AM »
that's very curious man, do you think it was the aspartate replenishing that got you this response??
Maybe! Or the Mg-Threonate. Or the Reishi. Unfortunately I can't tell yet, since I changed too many variables in the last week. It's a big topic for me, so I'll definitely report back on it.


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #10 on: June 21, 2021, 11:45:18 PM »
Days 9-12 (18 - 21 June 2021)

Intake
- Reishi, Lion's Mane, EGCG, Glycine (up to 10g), LOLA (1/2 tablespoon), occasionally D3, lipo C
- 15g oat bran on 20 June. Didn't feel that well the next day, but tolerance seems better than last week

Brain fog
Lion's mane does not seem to cause major brain fog anymore, so I'm kinda able to concentrate on work. I'm sure it would be way better without the LM, but I'm trying to keep it up as long as possible.

Immune reactions
I'm having lots of night sweats, but it's also super hot right now, so it could be just that.
Psoriasis had flared up a week ago, but seems to calm down now.
Gut bloating becomes worse on beta-glucans, but is better than usual without them. Still don't tolerate meat though, ate some grilled pork and chicken on the weekend and am quite bloated.

Overall wellness
I have more energy than usual, and when leaving away the beta-glucans I feel pretty great! My mood is also bright most of the time.


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #11 on: June 30, 2021, 06:00:24 AM »
(I did an oopsie - just divide all my previous Lion's Mane amounts by 4 and Reishi amounts by 2 🙄 The bottles give the amounts for multiple capsules instead of for one. Let's attribute this to the EGCG spaciness I had in the beginning.)

Days 13 - 21 (22 - 30 June)

Intake

Apart from 3 days last weekend (where I skipped Lion's Mane and EGCG), I did every day:
- 1.5-2g Reishi
- 1.5-2g Lion's Mane
- 570-780mg EGCG
- 3-5g Glycine (sometimes way more)

Also ate 15g oat bran twice, but that made me feel quite bad the next day. I'll reduce to 5g from now on and see how that goes.
Every second day I had ~5ml liposomal C (~500mg ascorbic acid)
Had a little K2 MK7 twice, and 2x ~10 micrograms Molybdenum.
Ca 70% of the days were fasting days with an 18h fasting window.


Immune reactions
- Night sweats are back to a normal level (considering the heat).
- Psoriasis is still there, but on the lower end.
- Gut bloating is quite bad, considering how much I'm IFing. I think there's an immune war waging down there.

Negative side effects

- Ca 12h after I drink potassium bicarbonate, I now get very hot and sweaty and generally very unwell. Lipo C fixed that very quickly, so maybe I now have a tendency towards alkalosis? I'll watch this closely.
- EGCG (and Glycine?) makes IF fasting a bit harder, making me feel as if I had fasted 2-3h longer than I actually did. That could also be a good thing of course, I just thought it belongs more in this section.
- Neck muscles and muscles around lower gut are chronically tight. Molybdenum und K2 seem to improve this. Coconut milk and nori algae make it way worse (probably iodine to blame). Maybe hyperparathyroid, I hope to get a lab soon.
- I'm cracking weird jokes and am generally sillier, but not in an actual funny way. Poor wifey! I sometimes sound like a nasty teen without a filter. That's almost certainly from Lion's mane, I observed this earlier when I made a soup out of a dried Lion's mane fruit body.
- Big amounts of Glycine trigger gut bloating. Small amounts taken in water seem to be not an issue.

Positive side effects

- I can actually sing for more than a minute without hurting! Talking is also mostly effortless now. Throat phlegm is almost gone, and probably just seasonal allergy related. This is a big deal for me, as I always had a semi-sore throat and a jumpy/vibrating voice.
- Eyes are less sunken, and I might look a bit younger. I have a vertical wrinkle between my eyebrows which is less pronounced now.

I think there would be more positive side effects, but the beta glucans and resulting reactions don't allow them for now.
« Last Edit: June 30, 2021, 06:05:12 AM by mmmm »


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #12 on: July 11, 2021, 02:22:12 PM »
Time for another progress report!

Days 22 - 32 (1 - 11 July)

Intake

Mostly I did a minimal stack again (didn't really stop Lion's Mane this time though, as brain fog is not really an issue anymore):
- 2-2.5g Reishi (increase from last period)
- 2-2.5g Lion's Mane (increase from last period)
- 570-780mg EGCG
- 6-10g Glycine (increase from last period)
- 5ml lipo C (500mg ascorbic acid) every other day
- ~1g Mg Threonate
- 100-200mg (probably) potassium gluconate
- Occasionally, Cordyceps ethanol extract (previously: hot water extract). Gives me anxiety if I take it every day, so I'm alternating.

Since two days I'm additionally having:

- 5g oat bran with some glycine
- Forskolin (first 80mg which was way too much, now ~20mg)
- 160mg Astragaloside IV
- 400mg Silymarin
- 600mg NAC - a bit hard to stomach but effects feel really good!

So far I'm really happy with these recent additions. Mood is good and feeling relaxed, especially NAC and Astragalus seem to do a lot there.

Ca 60% of the days were fasting days with an 18h fasting window. Had two "really bad" cake days and hope to make up for it with some more intensive fasting days now.

Also noteworthy: Started eating lettuce from our urban gardening patch a week ago, and mood improved a lot. Josh mentioned that it's a good idea to get dirty, and I took that up by eating some of the lettuce unwashed, and the rest only moderately washed ;D. I'm not sure whether it's the bacteria, or vit A or K1 that are to blame, but I'm really glad I'm returning to a more relaxed state 8)

Immune reactions

- Psoriasis is still there, but not bad
- Gut bloating got really bad when potassium went low (fluid retention especially around the waist and probably around gut). Now with potassium under control, constant bloating is still there but "normal" for me. Hope for this to go away down the road.

Negative side effects

- Still some zaniness towards other people (especially poor wifey). Just have a tendency to blurt out jokes of bad taste and regret it immediately. I still think that's the beta glucans.
- Not a part of the protocol, but maybe noteworth: It seems the Mg Threonate lowers potassium for me. I expect this to be a startup problem that will go away. The Mg Threonate might have also been to blame for the gut bloating I mentioned in the last post in connection with Glycine. Lowering the dose and combining with potassium seemed to fix that mostly, knock on wood.
- My right ear has been blocked/stuffed for a week now. I get this every summer ever since I had my first health decline, so I think that’s somehow HHB (EBV?) related.

The other negative side effects mentioned in the last post are now gone. The self-grown lettuce fixed the new muscle tightness (basal tightness remains though).


Positive side effects

Now getting to the exiting stuff!

- Throat health is still great! I think it's not swollen at all. Occasional phlegm seems to be directly related to seasonal allergies, as it occurs immediately after driving in the car.
- Chronically swollen lymph nodes disappear or reduce in mass. I had one on the back of my neck since age 14, and it's not palpable at all anymore. Also have one quite big one under the left armpit, which got definitely smaller and wandered down by a centimeter or so. This is really huge for me, as I thought those were permanent artefacts of Lyme infections in my youth.
- Gum and teeth health seems to improve. I almost got a (root canal treated) tooth pulled 2y ago, and it needed regular blue laser treatments to keep infections in check. That seems to be a thing of the past, knock on wood!
- Stool is consistently darker (better bile flow I assume), and I cautiously think digestion is improving. Need more time to really recognize a positive trend there.
- I think I have more stamina. Only seldomly need to sit down because I need to rest. I'm going for a walk most nights now, something I haven't done for a year. OTOH, I ate a lot of chocolate those last few days, so I need more data (and time) to really establish a positive trend.

Outlook

Looking forward to the next few days and seeing where this takes me.
In the long term, I would like to follow the full protocol, but still have a few reservations:

- Full fast for 3 days will probably not be possible with my responsibilities - family needs me too much right now, I'm basically a taxi when I'm not coding, and I'm not sure it's safe to drive when fasting with induced diarrhea, I'd be afraid of having a blackout or something. So I'll probably just skip the fast.

- The LifeExtension Mix capsules contain some things which I'm scared of. My last major health decline was either triggered by long-term (ab)use of Apple Cider Vinegar, or methylated B vitamins, or both. Or it could have been the bad Kefir batch which I chugged for a few months (it initially smelled like a solvent or paint thinner, but I "restarted" it with a trick from the internet which probably didn't really work - I'm still angry at myself for this). Hard to say, but I'm still wary of methylated B vitamins and Apple Cider Vinegar (outside of salads). My worry is mainly that I'd take those, and feel great for a few weeks and even months, and then crash for two years, like the last time around.

- I‘m still not completely over Cutler Chelation yet, and I will probably do a few more ALA rounds using that protocol. According to Cutler, ALA has a short half life in the body (a few hours) after which the bound metals are dropped into the bloodstream. Timing the doses according to that half life (during the day, max 3h apart, and 4h during the night) evens out ALA levels in the blood, allowing less metals to get redistributed into organs or the brain.
« Last Edit: July 11, 2021, 03:08:59 PM by mmmm »


  • mmmm
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    • June 13, 2021, 11:09:04 PM
Re: mmmm's blog
« Reply #13 on: July 23, 2021, 01:27:58 AM »
Days 33 - 44 (12 - 23 July)

I'll try a new format to make my posts easier to digest, and leave away things I think are not super relevant.

Stack (unchanged amount unless noted):
- Reishi, Lion's Mane, EGCG, Glycine daily
- NAC daily (600-1200mg)
- Molybdenum every other day (~10mg)
- Forskolin every other day (fasting days)
- Oat bran
  - So far: 5-15g once a week
  - Starting today: 60g 3x a week (Fri-Sun) + additional 10g whole Lion's mane
- Hesperidin + Naringin daily
- Berberine: 2x a week
- Triphala 3x a week (seems to overstimulate thyroid though)
- Curcumin LongVida - tried once. Read in the Discord that it chelates iron. The noot effect is great though! I'm torn. Will probably only use it when I absolutely need my brain to work well.

Progress
- Psoriasis got better, ca as well as in the time when I didn't eat any sugar or fruit for a year. But I do have sugar occasionally, so that's def an improvement!
- EDS like symptoms: Joints work better, and crack less often. Walking and standing feels more stable. Occasional hip pain is gone. I can now wear non-barefoot-shoes without subsequent pain. Connective tissue healing!
- Lymph nodes continue shrinking. The big one beneath the left armpit is even smaller and softer now, and moved 3cm down in total
- Face skin looks way fuller and more flexible than just 2 months ago
- Edema (full body water retention) that seems related to inflammation decreased, but not gone
- Negative effects of 2nd vaccination were almost non-existent (except for elevated temp for a few hours)
- (Intended) weight loss is continuing, with little to no muscle loss. Might have gained muscle actually.

I'm super stoked about the progress, and hungry for more!

Big big thanks to Josh and his wife, and the whole community for helping us! <3 <3 <3
« Last Edit: July 23, 2021, 01:49:33 AM by mmmm »


Re: mmmm's blog
« Reply #14 on: July 23, 2021, 01:40:10 PM »

Quote
- Molybdenum every other day (~10mg)



u wot