Research Group for ME/CFS, Chronic Disease, Aging and Cancer

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Enhanced water fasting, with disabled glutamate dehydrogenase
« on: August 26, 2021, 09:25:45 PM »
Purpose:

This enhanced fasting method targets selectively killing HHV / cancer / senescent cells using their metabolic differences as a selector, rather than requiring a functioning immune system for this function, as described from page 23/24 onwards in CFS/ME: A New Hope.

Materials needed:

NB. Supplements may NOT contain citrate, malate, fumarate or other mitochondrial energy source - check labels carefully.

Safety items -
1. Succinate (preferred) or Apple Cider Vinegar, as a source of succinic acid.
This is for rapidly exiting the fast, if needed.
https://www.amazon.com/Gluten-Free-Remedies-Succinic-Acid-250mg/dp/B00IFJC4GG/

Core items -
2. 3 x empty 1L bottles.

3. EGCG, as Green Tea Extract
Used to reduce the glutamate dehydrogenase (GDH) enzyme.
https://www.amazon.com/NOW-Supplements-Green-Extract-Capsules/dp/B001DNV5CA/

4. Sodium Chloride
Used to help maintain extracellular sodium levels. Use reagent grade or rock salt.)
https://www.amazon.com/dp/B000SWVKAE/

Recommended Extras -
5. Potassium Chloride
(Reagent grade / high purity. NOT: Nu-Salt, Morton’s Salt Substitute.)
Used to help maintain intracellular potassium levels.
https://www.amazon.com/NOW-Potassium-Chloride-Powder-8-Ounces/dp/B00028M02Q/

6. Magnesium Oxide
(Yes, really oxide. Yes, it's poorly absorbed and known to cause diarrhoea. That's the idea.)
Used to help maintain intracellular magnesium levels and also induce diarrhoea.
https://www.amazon.com/dp/B06VW5YP1Z/

7. Resveratrol
Used to alter glycolysis and improve fatty acid oxidation.
https://www.amazon.com/Ultra-Purity-Resveratrol-Capsules-Trans-Resveratrol/dp/B07R634S5D/

8. Forskolin
Used to increase cAMP and fatty acid oxidation.
https://www.amazon.com/Life-Extension-Forskolin-Vegetarian-Capsules/dp/B000LVG7J6/

9. Hesperidin
Used to maintain increased cAMP and fatty acid oxidation.
https://amazon.com/Hesperidin-Capsules-aurantium-Metabolic-Cardiovascular/dp/B0896VYQ9Y/

10. Caffeine
Used to increased fatty acid oxidation.
https://www.amazon.com/Bulksupplements-Caffeine-Capsules-gelatin-capsules/dp/B01IA8YFAE/

Fasting Schedule:

Day 1 | Induction - lower doses of EGCG, Resveratrol
Add the capsule contents to EACH 1L bottle (and discard / recycle the empty capsules) -
EGCG 75-100mg (eg. 1/2 capsule)
Sodium Chloride 2g
-
Potassium Chloride 3g
Magnesium Oxide 250-500mg
-
Resveratrol 50-150mg (eg. 1/2 capsule)
Forskolin 10mg
Hesperidin 250-500mg
Caffeine (low dose - as desirable / tolerable)
Fill the rest of each 1L bottle with water. Shake well.

Day 2 | Full strength dosing, GI flush
Add the capsule contents to EACH 1L bottle (and discard / recycle the empty capsules) -
EGCG 500-600mg (eg. 3 capsules)
Sodium Chloride 2g
-
Potassium Chloride 3g
Magnesium Oxide 250-500mg
-
Resveratrol 300-500mg (eg. 2-3 capsules)
Forskolin 10mg
Hesperidin 250-500mg
Caffeine (low dose - as desirable / tolerable)
Fill the rest of each 1L bottle with water. Shake well.

Day 3+ | Full strength dosing, optional GI flush
Add the capsule contents to EACH 1L bottle (and discard / recycle the empty capsules) -
EGCG 500-600mg (eg. 3 capsules)
Sodium Chloride 2g
-
Potassium Chloride 3g
Magnesium Oxide 250-500mg (can remove if GI tract is now clear)
-
Resveratrol 300-500mg (eg. 2-3 capsules)
Forskolin 10mg
Hesperidin 250-500mg
Caffeine (low dose - as desirable / tolerable)
Fill the rest of each 1L bottle with water. Shake well.

Strictly:
NO food consumption for 6-8 hours after your last EGCG dose - food will HURT you by shutting off energy generation in your mitochondria.

According to expectations derived from the literature (and confirmed by a small number of reports from people who did not follow this advice), consuming any food during this 6-8 hour window will likely cause someone to be blacking in/out and convulsing in pain for the remaining hours, unless someone else places 100mg of succinate in this person's mouth, as they will likely be unable to
(This could easily be fatal, if you were eg. driving a motor vehicle or operating heavy machinery.)

Have succinate/succinic acid (or some high strength apple cider vinegar, which contains succinic acid) on hand in case you want to rapidly exit the fast, at 100mg. Otherwise, simply do not eat for 6-8 hours after your last dose of EGCG.

NO other supplements are to consumed.

Any medications which must be maintained due to tolerance or withdrawal symptoms should be continued. Antibiotics and antiviral can be combined with this fasting protocol.

Guidance:
Cannabis is allowed, where legal.
-THC may increase appetite, which could be problematic if not well-tolerated.
-CBD may decrease appetite and improve sleep.

You may freely drink additional plain water.

If the high dose EGCG flavour is intensely unpalatable, the capsules can be taken every 4-5 hours instead of mixed into the water.
Some optional flavouring could also be considered, however finding a compatible flavouring agent is problematic.
https://www.amazon.com/SweetLeaf-Sweet-Liquid-Stevia-Sweetener/dp/B00B7V6YHY/
(Supplements may NOT contain citrate, malate, fumarate or other mitochondrial reaction source metabolite - check labels carefully.)

Be prepared to have loose stools. This may have benefits for SIBO, etc.
Be prepared to experience inflammation, unusual pains, rashes, etc., in any infected tissues.
This is a necessary physiological unpleasantness - there is currently no road back to health that avoids tissue remediation.

Creating a calm environment and set aside this fasting time away from work and other life pressures is highly recommended.
NB. I am NOT a doctor and all information provided is for educational purposes only.

Please consult your physician before attempting anything you read here.