The symptoms are largely relating to cAMP-PKA-CREB homeostasis, can be potentially life-threatening / self-harm inducing and are expected to appear and disappear multiple times over typically 2-3 weeks, like a swinging pendulum over-shooting, on its way back to the center, where homeostasis is restored (see Figure 18 on the disease model page for additional information).

With each swing, one direction has a "drugged" feeling (low cAMP-PKA tone) and the other direction includes panic, depression, elevated heart-rate, insomnia, etc. (elevated cAMP-PKA tone). Hormonal status greatly controls this pathway and for females, it would be distinctly advantageous to start any endogenous opioid withdrawal process just after menses. Oestradiol amplifies excessive cAMP signalling and progesterone calms it. During excessive cAMP signalling, any adrenergic triggers will be amplified - small signals can easily become panic, terror and spiralling. This may also explain why women suffer from neuropsychiatric symptoms manifest at different stages of their menstrual cycle (pre-ovulation and luteal phase) and why they are more likely to suffer when this pathway loses homeostasis than men, generally. More understanding and empathy around this could help inform appropriate patient care.

As this process usually accompanies restored NAD+ pool status, being the primary currency and sensor for cortisol's regulation of innate immune activity  (XO,  and NOS, NOX - via further NAD+ conversion to NADPH), it's expected that any tissue with an active infection or tissue repair functions orchestrated by IFN-gamma activity will flare with inflammation and pain. This can feed into adrenergic signalling to promote cAMP.

Both of these processes can be "cushioned" and managed to make them tolerable.

Ironically, the logical solution is fairly simple, although it may understandably raise some initial concerns.

It has often been said that "alcohol is the cause of and solution to all of life's problems" and never more literally than in this instance.

This observation has been shared by various well-known people with ME/CFS and related online groups such as https://www.reddit.com/r/hangovereffect/.

Although this author's opinion is bound to attract some criticism, I'd also advocate that using exogenous alcohol, as an over-the-counter tapering schedule against withdrawal from the microbial-sourced alcohol (and the 2 downstream endogenous psychoactive substances) is a far simpler and less problematic therapeutic intervention than administering exogenous opioids and/or benzodiazepines, in an attempt to create an effective tapering schedule.

These 2 classes of drugs are both well-known to be "drugs of dependence" and will likely require high doses to be effective symptomatically. High doses of these interventions can create a long tapering schedule of their own that may last 6 months to a year and is known to be highly unpleasant.

Following a strict alcohol tapering schedule and avoiding dosing at levels which induce alcoholic intoxication is required. The goal is to remain in a tolerable level of withdrawal symptoms during the taper, rather than attempting to make the process "feel pleasurable" and extending the process. This will be highly personalised and likely involve multiple doses over the day / night, which decrease over time. Having appropriate monitoring and management would be highly advisable.

Caveats and Risks
1) It would be optimal to avoid alcohol reaching the gut microbiome. Neat alcohol such as gin, vodka or whiskey, when taken in small sips and absorbed largely via the mucous membranes found in the mouth, throat and oesophagus would be a preferred route of administration. These can be attempted at 1/2 a "typical" drink, eg. 15ml of neat spirits, or 1/2 a beer / wine / cider, etc. and allow 20-30 minutes to test if stability / relief has been achieved.

2) While alcohol add-back therapy is known to be problematic in chronic alcohol use withdrawal due to the risk of behavioral disorders, such issues are less likely to arise in conditions like ME/CFS or Long COVID where alcohol consumption was not voluntary or habitual. However, professional oversight and adequate peer support is still recommended to manage the process effectively and provide a safety-net.

Cinnamon contains compounds which also inhibit ALDH and can provide some tapering support for a few hours per dose. Effective dosing ranges may span from 1/10th to 1 teaspoon of cinnamon powder. 
NB. Excess amounts of cinnamon can trigger a "drugged" or "drunk" feeling.