{"id":351,"date":"2024-07-08T06:12:29","date_gmt":"2024-07-07T19:12:29","guid":{"rendered":"https:\/\/bornfree.life\/2024\/?p=351"},"modified":"2026-03-21T08:45:23","modified_gmt":"2026-03-20T21:45:23","slug":"2-3-2-remineralisation","status":"publish","type":"post","link":"https:\/\/bornfree.life\/learn\/2-3-2-remineralisation\/","title":{"rendered":"2.3.2 Remineralisation"},"content":{"rendered":"\n\n\n

\n 2.3.2 Remineralisation <\/h1><\/a>\n\n <\/div>\n\n

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<\/strong>One of the biggest challenges for remineralisation with chronic disease and inflammation is absorption. <\/strong>The
disease model shows this is mostly related to elevated TNF-\u03b1, IL-1\u03b2, IL-6, IL-10, IL-22 -> hepcidin, which then inhibits 2 metal transporters – Divalent Metal Transporter (DMT-1) & ferroportin. This further inhibits dietary intake and circulation of at least 11
metals, by sequestering them in specific cells \/ tissues (brain, liver, kidneys, spleen). 

These known metals are Iron (Fe), Manganese (Mn), Copper (Cu), Zinc (Zn), Cobalt (Co), Molybdenum (Mo), Nickel (Ni), Cadmium (Cd), Lead (Pb), Vanadium (V) and Selenium (Se), in their 2+ state.

<\/strong>This hepcidin-mediated mechanism appears to benefit the host during acute<\/strong> immune activity by depriving circulating pathogens of iron and other minerals which may help their proliferation.

During chronic<\/strong> immune activity (ie. failure to clear the acute infection, due to pathogen evolution and immune surveillance “blind spots” + dysregulation), this hepcidin-mediated cascade leads to depletion of these metals, via dietary blockade during the inflammatory state. 

Coupled with this blockade is progressively worse acidaemia from from a lowered lactate threshold, due to progressively worse mitochondrial dysfunction and enhanced renal excretion of zinc and electrolytes. (see Figure 12<\/a> on the disease model page and 2.2.4 The importance of pacing<\/a>)

The more frequent the chronic inflammatory spikes, the more difficult it is to absorb these metals from diet, as they’ll be actively rejected. ie. The deeper into the ME\/CFS spiral you are, the harder it is to recover the minerals via diet and oral supplementation and the more effort you’ll need to put into rebuilding and maintaining their systemic levels. 

This means non-oral routes or special tricks to bypass the standard mineral transporters are required for an initial repletion period and progressively less so as the inflammatory cascade is corrected. 

According to the literature, a 70kg human body normally maintains an optimal level of many elements needed for enzymatic and other processes. 

The amount of each element stored also appears to have a relationship with the severity of the metabolic impact experienced, if deficient, eg. oxygen deficiency creates severe and fairly rapid dysfunction. 

Based on the table of elements below, this further suggests that future studies may find overlooked biological advantages in our bodies naturally maintaining a certain amount of eg. lead – perhaps, hypothetically (and purely speculatively) providing resilience against high-energy radiation?

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\n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
\n element <\/td>\n \n mass <\/td>\n \n element <\/td>\n \n mass <\/td>\n \n element <\/td>\n \n mass <\/td>\n \n element <\/td>\n \n mass <\/td>\n <\/tr>\n
\n Oxygen <\/td>\n \n 45kg <\/td>\n \n Gallium <\/td>\n \n 700mg <\/td>\n \n Nickel <\/td>\n \n 15mg <\/td>\n \n Lanthanum <\/td>\n \n 800\u03bcg <\/td>\n <\/tr>\n
\n Carbon <\/td>\n \n 13kg <\/td>\n \n Rubidium <\/td>\n \n 680mg <\/td>\n \n Chromium <\/td>\n \n 14mg <\/td>\n \n Tellurium <\/td>\n \n 700\u03bcg <\/td>\n <\/tr>\n
\n Hydrogen <\/td>\n \n 8kg <\/td>\n \n Strontium <\/td>\n \n 320mg <\/td>\n \n Manganese <\/td>\n \n 12mg <\/td>\n \n Yttrium <\/td>\n \n 600\u03bcg <\/td>\n <\/tr>\n
\n Nitrogen <\/td>\n \n 1.8kg <\/td>\n \n Bromine <\/td>\n \n 260mg <\/td>\n \n Arsenic <\/td>\n \n 7mg <\/td>\n \n Bismuth <\/td>\n \n 500\u03bcg <\/td>\n <\/tr>\n
\n Calcium <\/td>\n \n 1kg <\/td>\n \n Lead <\/td>\n \n 120mg <\/td>\n \n Lithium <\/td>\n \n 7mg <\/td>\n \n Thallium <\/td>\n \n 500\u03bcg <\/td>\n <\/tr>\n
\n Phosphorus <\/td>\n \n 780g <\/td>\n \n Copper <\/td>\n \n 72mg <\/td>\n \n Ruthenium <\/td>\n \n 7mg <\/td>\n \n Indium <\/td>\n \n 400\u03bcg <\/td>\n <\/tr>\n
\n Potassium <\/td>\n \n 140g <\/td>\n \n Aluminium <\/td>\n \n 60mg <\/td>\n \n Mercury <\/td>\n \n 6mg <\/td>\n \n Gold <\/td>\n \n 200\u03bcg <\/td>\n <\/tr>\n
\n Sulphur <\/td>\n \n 140g <\/td>\n \n Cadmium <\/td>\n \n 50mg <\/td>\n \n Caesium <\/td>\n \n 6mg <\/td>\n \n Scandium <\/td>\n \n 200\u03bcg <\/td>\n <\/tr>\n
\n Sodium <\/td>\n \n 100g <\/td>\n \n Cerium <\/td>\n \n 40mg <\/td>\n \n Molybdenum <\/td>\n \n 5mg <\/td>\n \n Tantalum <\/td>\n \n 200\u03bcg <\/td>\n <\/tr>\n
\n Chlorine <\/td>\n \n 95g <\/td>\n \n Barium <\/td>\n \n 22mg <\/td>\n \n Germanium <\/td>\n \n 5mg <\/td>\n \n Vanadium <\/td>\n \n 110\u03bcg <\/td>\n <\/tr>\n
\n Magnesium <\/td>\n \n 19g <\/td>\n \n Tin <\/td>\n \n 20mg <\/td>\n \n Cobalt <\/td>\n \n 4mg <\/td>\n \n Thorium <\/td>\n \n 100\u03bcg <\/td>\n <\/tr>\n
\n Iron <\/td>\n \n 4.2g <\/td>\n \n Iodine <\/td>\n \n 20mg <\/td>\n \n Antimony <\/td>\n \n 2mg <\/td>\n \n Uranium <\/td>\n \n 100\u03bcg <\/td>\n <\/tr>\n
\n Fluorine <\/td>\n \n 2.6g <\/td>\n \n Titanium <\/td>\n \n 20mg <\/td>\n \n Silver <\/td>\n \n 2mg <\/td>\n \n Samarium <\/td>\n \n 50\u03bcg <\/td>\n <\/tr>\n
\n Zinc <\/td>\n \n 2.3g <\/td>\n \n Boron <\/td>\n \n 18mg <\/td>\n \n Niobium <\/td>\n \n 1.5mg <\/td>\n \n Tungsten <\/td>\n \n 20\u03bcg <\/td>\n <\/tr>\n
\n Silicon <\/td>\n \n 1g <\/td>\n \n Selenium <\/td>\n \n 15mg <\/td>\n \n Zirconium <\/td>\n \n 1mg <\/td>\n \n Beryllium <\/td>\n \n 36\u03bcg <\/td>\n <\/tr>\n <\/table>\n<\/div>