{"id":3463,"date":"2025-09-27T00:08:19","date_gmt":"2025-09-26T13:08:19","guid":{"rendered":"https:\/\/bornfree.life\/2024\/?page_id=3463"},"modified":"2026-03-14T17:20:35","modified_gmt":"2026-03-14T06:20:35","slug":"mosaicdx-tool","status":"publish","type":"page","link":"https:\/\/bornfree.life\/learn\/mosaicdx-tool\/","title":{"rendered":"MosaicDX OAT Interpreter"},"content":{"rendered":"\n\n\n

\n MosaicDX OAT Interpreter <\/h1><\/a>\n\n <\/div>\n\n

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<\/p>\nThis is early release of an unofficial<\/em> interpretation tool for MosaicDX’s Organic Acids Test (OAT)<\/strong><\/a> report. 
[Dictionary 20260102-1, pre-release for testing purpose – rules are still being added and\/or refined<\/strong>]<\/em>

Recent Updates:<\/strong>
[16th December 2025]: Figure 1<\/a> on the Disease Model page now displays most OAT marker numbers adjacent to metabolites, for people who enjoy visual learning.
[18th December 2025]:<\/span> The new-and-improved 2025 Rev3 \nMosaic OAT reports now work with this \ntool.
[14th March 2026]: The new 2026 v4 Mosaic OAT reports now also work cleanly.  <\/span> <\/span>

Background:<\/strong> 
MosaicDX Organic Acids Test (OAT) is a very useful panel [sample report download<\/a>] for evaluating catabolic energy metabolism and other key pathways over a defined fasting period + sleep. However, manual interpretation of these reports requires a skill-set and\/or billing schedule that is out-of-scope for many point-of-care scenarios. There are known issues where if specimens thaw in transit, are delayed or when creatinine is sufficiently out-of-range, these problems can cause a left or right shift to many values. These reports also lack \ninferences for intracellular coenzyme, electrolyte and mineral status, \nwhich can be provided by the array of analytes reported.

Current features:<\/strong> 
1)\n Client-side javascript extracts the analytes, values and ranges from an unmodified (English, 2023-2025 layout) MosaicDX OAT results PDF, displays them on-screen with a LOW, \nIN-RANGE LOW, IN-RANGE HIGH, HIGH status, Deviation% and provides a download function as CSV<\/strong> that includes a large number of additional columns. 

2) Left or right shift in results, when identified, can be manually compensated for by adjusting the Shift Correction% input field +\/- from 100%. A left-shift score is calculated in the totals. Total scores of 50% or above in Req_ShiftCorr suggests shift correction may be appropriate. A common left-shift correction value may be around 150%. 

3) The extracted LOW and IR-LOW analyte values and dictionary-based rules score inferences for required cofactors (as coenzymes \/ minerals \/ \nelectrolytes, etc) and the sum of these scores are compared to the total possible score and displayed as a percentage. The higher confidence percentage, \nthe more confidence in a specific cofactor deficiency is inferred. Currently, a confidence score above 30% should be treated as a progressively positive indication of deficiency. This will be refined in future updates, when mitochondrial and cytosolic cofactors are separated<\/strong>. \nUpstream reactions can also be included as required cofactors, with \nlower ‘weights’ recorded. 

4) A default dictionary is installed (and being further improved)<\/em>. While I’d encourage people to share any rules \/ patterns they’d like to include<\/strong>, your own personal dictionary file can also be used. You can download<\/a> and\n extend the existing dictionary schema by adding columns labelled \n“Req_<cofactor>” and these will be included in the calculations \/ \ntotal. Additional rules can also be defined in the dictionary file, \nevaluating the variance between the Deviation% of 2 analytes, against a threshold%. If this is exceeded, the rule status is set to TRUE and is included in \nthe total flags for cofactors. ie. if Succinic : Fumaric acid ratio is elevated, FAD, Fe, S, CoQ10 are flagged as potentially low. If the rule’s Analyte#2 is “0”, the variance% is calculated against ideal (0%). This allows for rules to be created against a single analyte’s value.

<\/p>\n

Notes:<\/strong>
1) A deficiency of one redox currency state, eg. NADP implies an excess of the other state, eg. NADPH.
2) Indicated acetyl-CoA deficiency without indicated CoA deficiency suggests glycogen homeostasis \/ fatty acid oxidation issues.<\/p>

3) Fe, O2 and antioxidant (Vitamin C \/BH4) are used as cofactors in the same hydroxylase reactions, meaning that a deficiency in any 1 of these can impair the reaction and confound the deficiency results for the others. Interpret with caution.<\/strong>
4) Broadly low ATP, TPP, FAD, NAD, P5P, CoA + Acetyl-CoA can indicate low P. <\/p>

5) Mobile UI portrait mode support is limited, due to rich table content. Javascript must be enabled in your browser for this tool to work.
6) Nordic Labs rebranded Mosaic OAT reports<\/strong> are currently not working accurately – extraction for the last marker on each page is affected by the layout differences<\/strong>. This will be corrected in a future update, soon. <\/p>\n


Privacy statement:<\/strong> 
No data (the MosaicDX OAT report or otherwise) is transmitted by your browser, let alone stored on this (or any other) server when using this tool.<\/strong> 
“Upload” buttons on this page are only “uploading” them into your browser cache. 
All processing is performed locally, in your web browser.

<\/em><\/strong><\/p>\n

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Disclaimer:<\/em><\/strong>
MosaicDX and \u2018OAT\u2019 are used\n nominatively to identify the compatible PDF \nreport. Born Free is not affiliated with, endorsed by, or sponsored by \nMosaicDX. For support with MosaicDX\u2019s official reports, contact MosaicDX\n directly; this tool is community-built and independent. 

Information is general and not medical advice. Outputs\n are experimental and may contain errors. Do not use for diagnosis or \nclinical decisions; seek advice from a qualified health professional. \nThis tool is provided for research\/education to help read report PDFs. \nIt is not intended to diagnose, treat, prevent or monitor disease, and \nis not intended for clinical decision-support. If you use software for \nsuch purposes, you are responsible for complying with applicable \nregulations.

This tool is provided \u2018as is\u2019: we don\u2019t warrant \ncompleteness or accuracy and exclude all implied warranties to the \nmaximum extent permitted by law.  <\/em><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"class_list":["post-3463","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages\/3463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/comments?post=3463"}],"version-history":[{"count":4,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages\/3463\/revisions"}],"predecessor-version":[{"id":4647,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages\/3463\/revisions\/4647"}],"wp:attachment":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/media?parent=3463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}