{"id":3410,"date":"2025-09-18T13:06:17","date_gmt":"2025-09-18T02:06:17","guid":{"rendered":"https:\/\/bornfree.life\/2024\/?page_id=3410"},"modified":"2026-02-04T16:36:55","modified_gmt":"2026-02-04T05:36:55","slug":"theriome-tool","status":"publish","type":"page","link":"https:\/\/bornfree.life\/learn\/theriome-tool\/","title":{"rendered":"Theriome Aristotle Interpreter"},"content":{"rendered":"\n\n\n

\n Theriome Aristotle Interpreter <\/h1><\/a>\n\n <\/div>\n\n

<\/div>


<\/p>\nThis is an unofficial<\/em> interpretation tool for Theriome’s Aristotle<\/strong><\/a> report.
[v3.6.8 Dictionary 20260202-1]<\/em>

Background:<\/strong>\n Theriome have produced a lovely panel of analytes<\/a> (example report)<\/em> for evaluating \npathways. However, I feel these reports could be better optimised for \ntime-efficient interpretation. They also lack \ninferences for intracellular coenzyme, electrolyte and mineral status, \nwhich can be provided by the array of analytes reported. 

Current features:<\/strong> 
1)\n Client-side javascript extracts the analytes, values and ranges from pages \n25-66 of the Aristotle report PDF, displays them on-screen with a LOW, \nIN-RANGE LOW, IN-RANGE HIGH, HIGH status, Deviation% and provides a download function as CSV or PDF<\/strong>. 
2) The analyte values are compared to a\n dictionary file, which flags cofactors – coenzymes \/ minerals \/ \nelectrolytes required to produce and\/or degrade that analyte. These flags are summed for \nall analytes, compared to the total possible, then scored and displayed as a bar graph percentage. The higher the score, \nthe more confidence in a specific inferred cofactor deficiency is provided. Currently, a score above 30% should be treated as a progressively positive indication of deficiency. This will be refined in future updates, when mitochondrial and cytosolic cofactors are separated<\/strong>. \nUpstream reactions can also be included as required cofactors, with \nlower ‘weights’ recorded. 
3) A default dictionary is installed (and being further improved)<\/em>,\n however your own dictionary file can also be used. You can download<\/a> and\n extend the existing dictionary schema by adding columns labelled \n“Req_<cofactor>” and these will be included in the calculations \/ \ntotal. Additional rules can also be defined in the dictionary file, \nevaluating the variance between 2 analytes against a threshold%, where \nif this is exceeded, the rule status is set to TRUE and is included in \nthe total flags for cofactors. ie. if Succinic Acid -> Fumaric Acid \nis out-of-range, FAD, Fe, S, CoQ10 are flagged as potentially low. If the rule’s Analyte#2 is “0”, the variance% is calculated against ideal (0%). This allows for rules to be created against a single analyte’s value.

\nNotes:<\/strong>
1) A deficiency of one redox currency state, eg. NADP implies an excess of the other state, eg. NADPH.
2) This is an early-release dictionary and a significant list of rules will be added.<\/strong>\n
Privacy statement:<\/strong> 
No data (the Theriome report or otherwise) is transmitted by your browser, let alone stored on this (or any other) server.<\/strong> 
“Upload” buttons on this page are only “uploading” them into your browser cache. 
All processing is performed locally, in your web browser.
<\/em><\/strong>
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\n \n <\/div>\n
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Disclaimer:<\/strong>
Theriome\n and \u2018Aristotle\u2019 are used nominatively to identify the compatible PDF \nreport. Born Free is not affiliated with, endorsed by, or sponsored by \nTheriome. This page refers only to Theriome\u2019s metabolomic \u2018Aristotle\u2019 \nreport and not to StageZero Life Sciences\u2019 ARISTOTLE\u00ae multi-cancer test.\n For support with Theriome\u2019s official reports, contact Theriome \ndirectly; this tool is community-built and independent. 

Information is general and not medical advice. Outputs\n are experimental and may contain errors. Do not use for diagnosis or \nclinical decisions; seek advice from a qualified health professional. \nThis tool is provided for research\/education to help read report PDFs. \nIt is not intended to diagnose, treat, prevent or monitor disease, and \nis not intended for clinical decision-support. If you use software for \nsuch purposes, you are responsible for complying with applicable \nregulation.

This tool is provided \u2018as is\u2019: we don\u2019t warrant \ncompleteness or accuracy and exclude all implied warranties to the \nmaximum extent permitted by law. <\/em><\/p>\n\n\n\n\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"class_list":["post-3410","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages\/3410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/comments?post=3410"}],"version-history":[{"count":0,"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/pages\/3410\/revisions"}],"wp:attachment":[{"href":"https:\/\/bornfree.life\/learn\/wp-json\/wp\/v2\/media?parent=3410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}